Evidence map›Paper›PMID 40698762›Full record

Observational studyLiver international : official journal of the International Association for the Study of the Liver2025

Thigh Muscles and Metabolic Dysfunction-Associated Steatotic Liver Disease: Findings From the SCAPIS/IGT-Microbiota Study.

Amar Osmancevic, Anders Gummesson, Matthew Allison, Joel Kullberg, Ying Li, Göran Bergström, Bledar Daka

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Thigh Muscles and Metabolic Dysfunction-Associated Steatotic Liver Disease: Findings From the SCAPIS/IGT-Microbiota Study.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amar OsmancevicGeneral Practice/Family Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-2774-0194
Anders GummessonDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Matthew AllisonDivision of Preventive Medicine, School of Medicine, UC San Diego, San Diego, California, USA.
Joel KullbergRadiology, Department of Surgical Sciences, Uppsala University, Sweden.
Ying LiGeneral Practice/Family Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Göran BergströmDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Bledar DakaGeneral Practice/Family Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

ALF funding from Region Västra Götaland ALFGBG-1006749ALF funding from Region Västra Götaland ALFGBG-718101ALF funding from Region Västra Götaland ALFGBG-718851Research and Development Centre Gothenburg and Södra BohuslänSwedish Heart Lung Foundation 20180600Swedish Heart Lung Foundation 20210366Swedish Heart Lung Foundation 20210383Swedish Research Council 2019-01140
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe relationship between skeletal muscle features and hepatic fat infiltration remains understudied. To address this knowledge gap, a cross-sectional observational study was conducted using data from two ancillary studies of the SCAPIS cohort.

methodThe study aimed to examine the relationship between skeletal thigh muscle radiodensity (Hounsfield Units, HU) and area (cm

resultsResults showed a positive significant association between thigh muscle area and MASLD (OR = 1.29, 95% CI 1.02, 1.62, p = 0.033), and a negative association with hepatic radiodensity (B = -0.76, 95% CI -1.19, -0.34, p = 0.001), independent of muscle radiodensity. Additionally, a significant association was observed between muscle radiodensity and hepatic radiodensity (B = 0.37, 95% 0.09, 0.64, p = 0.008). Finally, sex differences were notable in the association between thigh muscle area and MASLD (F-test = 0.10). Specifically, we observed statistically significant associations between thigh muscle features and liver density/MASLD in men, but not in women.

conclusionConclusively, increased thigh muscle volume was associated with greater odds of MASLD and hepatic steatosis, independent of muscle radiodensity. Yet, greater thigh muscle radiodensity was associated with decreased odds of hepatic steatosis, regardless of the muscle volume. Furthermore, a sex difference was observed in our study, underscoring the importance of considering sex-specific factors on the development of MASLD.

Indexed as

Fatty LiverMuscle, SkeletalNon-alcoholic Fatty Liver DiseaseThighAdultAgedCross-Sectional StudiesFemaleHumansLinear ModelsLiverMaleMiddle AgedTomography, X-Ray Computedepidemiologyfatty livermetabolic‐associated fatty liver diseaseskeletal muscle

Identifiers

PMID40698762
PMCPMC12285211

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.