Evidence map›Paper›PMID 40698944›Full record

ArticleChronobiology international2025

Adolescent dietary patterns and methyl-donor nutrient intakes in relation to blood leukocyte DNA methylation of circadian genes.

Jennifer T Lee, Jaclyn M Goodrich, Dana C Dolinoy, Karen E Peterson, Martha M Téllez-Rojo, Alejandra Cantoral, Libni A Torres-Olascoaga, Edward A Ruiz-Narváez, Erica C Jansen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronobiology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer T LeeDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Jaclyn M GoodrichDepartment of Environmental Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Dana C DolinoyDepartment of Environmental Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Karen E PetersonDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Martha M Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Alejandra CantoralCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Libni A Torres-OlascoagaCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Edward A Ruiz-NarváezDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Erica C JansenDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3M
Environmental Epigenomics and Precision Environmental HealthR35ES031686 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2020 to 2026
$6.1M
Multi-Institutional Training in Genetic/Genomic Approaches to Sleep DisordersT32HL110952 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHERVIN, RONALD D, MIGNOT, EMMANUEL J · 2013 to 2022
$5.0M
Project 3: Developmental Exposures and Diet: Epigenetics of Metabolic SyndromeP01ES022844 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PADMANABHAN, VASANTHA, PETERSON, KAREN EILEEN · 2013 to 2018
$3.9M
Sleep and Circadian Rhythms in Adolescence: Epigenetic Pathways of Cardiometabolic RiskK01HL151673 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JANSEN, ERICA CHRISTINE · 2020 to 2024
$759k
NHLBI NIH HHS K01 HL151673NHLBI NIH HHS T32 HL110952NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIEHS NIH HHS P01 ES022844NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R35 ES031686
6 · The paper itself

Abstract

Dietary composition may impact circadian rhythms, potentially through DNA methylation of circadian genes. However, research among adolescents remains limited. Cross-sectional association of three dietary patterns, derived from principal component analysis of energy-adjusted food groups, and five energy-adjusted methyl-donor nutrients (folate, methionine, riboflavin, and vitamins B6 and B12) on DNA methylation of 18 circadian-related genes in 526 adolescents was examined. DNA methylation levels at CpG sites were quantified from blood leukocytes using the Illumina Infinium Methylation EPIC BeadChip, with false discovery rate adjustments (

Indexed as

Circadian RhythmDietDNA MethylationFeeding BehaviorLeukocytesNutrientsAdolescentCpG IslandsCross-Sectional StudiesFemaleHumansMaleRiboflavinNutrientsRiboflavincircadian genesclock genesdietary intakeDietary patternsDNA methylationepigeneticsmethyl-donor nutrients

Identifiers

PMID40698944
PMCPMC12366751

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.