ArticleArquivos brasileiros de oftalmologia2025
Evaluation of retinal nerve fiber and ganglion cell layer abnormalities using optical coherence tomography in thyroid-associated orbitopathy.
Article in Arquivos brasileiros de oftalmologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to evaluate abnormalities in the retinal nerve fiber layer and ganglion cell layer in patients with thyroid-associated orbitopathy using optical coherence tomography and to examine their relationship with disease severity.
methodsA cross-sectional study was conducted involving 74 participants, comprising 45 individuals with thyroid-associated orbitopathy and 29 healthy controls. All subjects underwent a comprehensive ophthalmological examination and optical coherence tomography using the Cirrus HD-OCT. The clinical activity score and the European Group on Graves' Orbitopathy severity were also evaluated.
resultsIn the thyroid-associated orbitopathy group, the mean peripapillary retinal nerve fiber layer thickness was significantly reduced in the temporal quadrant (p<0.05). No significant differences were found in ganglion cell layer thickness across all sectors when compared with the control group. Besides, a significant correlation was observed between orbitopathy severity and decreased mean peripapillary retinal nerve fiber layer thickness (p<0.001).
conclusionOptical coherence tomography may serve as a useful tool for identifying changes in the retinal nerve fiber layer and ganglion cell layer in patients with thyroid-associated orbitopathy, including in the inactive phase and prior to the clinical manifestation of dysthyroid optic neuropathy. It may be a helpful adjunct in monitoring disease progression.
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