ReviewAdvances in therapy2025
Obstructive Sleep Apnea: An Evolving Therapeutic Landscape with an Emerging Role for Incretin-Based Therapies.
Review in Advances in therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of SGLT2 inhibitors, GLP-1 receptor agonists, and aerobic exercise for moderate-to-severe obstructive sleep apnea in overweight or obese patients: a network meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Obstructive sleep apnea and seizures: pathophysiological mechanisms and clinical implications: a narrative review.Sleep & breathing = Schlaf & Atmung · 2026Review
- Comparative impact of different weight loss strategies on obstructive sleep apnea: an integrated review of surgical, pharmacological, and lifestyle interventions.Frontiers in neurology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by repetitive collapse of the upper airway during sleep, resulting in intermittent hypoxemia and sleep fragmentation. OSA is a highly prevalent condition, strongly associated with obesity and linked to an increased risk of cardiovascular disease. While traditional therapies such as positive airway pressure (PAP) devices are effective in treating OSA and alleviating daytime symptoms, they are often not well tolerated and have limited impact on long-term cardiovascular outcomes. As our understanding of the heterogenous factors driving OSA advances, novel therapies targeting specific physiological traits-such as arousal threshold, ventilatory instability, and upper airway muscle responsiveness-are being actively explored, with a promise to expand our therapeutic arsenal. Notably, the recent approval of tirzepatide for the treatment of obesity-related OSA marks a significant milestone in this evolving therapeutic landscape. This incretin-based drug, previously approved for diabetes and obesity management, offers dual benefits, promoting weight loss and improving OSA severity and symptoms. Given this therapeutic evolution in the OSA landscape over the last decade, this review provides a comprehensive overview of the current and emerging treatment strategies for personalized OSA management, with a particular emphasis on the growing role and promise of incretin-based therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.