Evidence map›Paper›PMID 40699484›Full record

SynthesisGeroScience2026

Cross-sectional and longitudinal associations of circulating bile acids and dementia: a systematic review.

Yasi Zhang, Jialin Li, Jincheng Li, Yingzhe Wang, Mei Cui, Wenyan Li, Xingdong Chen, Yanfeng Jiang

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yasi ZhangHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 200433, China.
Jialin LiHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 200433, China.
Jincheng LiHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 200433, China.
Yingzhe WangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, 200,040, China.
Mei CuiDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, 200,040, China.
Wenyan LiENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200,031, China.
Xingdong ChenFudan University Taizhou Institute of Health Sciences, Taizhou, 225,326, Jiangsu, China.
Yanfeng JiangHuman Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, 200433, China. yanfengjiang@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4976-6333

Funding

National Key R&D Program of China 2023YFC3606304National Natural Science Foundation of China 82373658Natural Science Foundation of Shanghai, China 22ZR1405300Science and Technology Innovation 2030 Major Projects 2022ZD0211600
6 · The paper itself

Abstract

Bile acids (BAs) may contribute to dementia by regulating neuroinflammation and influencing gut-brain axis signaling, especially in Alzheimer's disease (AD). However, their alterations in dementia development are rather complex and their impact on dementia risk remains inconclusive. To provide a comprehensive understanding of these associations, we systematically reviewed cross-sectional and longitudinal studies on circulating BAs and dementia. We conducted a systematic search of PubMed, EMBASE, and Cochrane Library from inception to August 15, 2024, for population-based observational studies investigating the changes in circulating BAs and the association between BAs and dementia risk. A total of twelve articles were eligible for inclusion, including eleven cross-sectional studies and three longitudinal studies (with two studies overlapping). Cross-sectional studies showed that, compared to cognitively normal individuals, the circulating level of primary BAs such as cholic acid (CA) is reduced, while glycochenodeoxycholic acid (GCDCA) and most secondary bile acids are increased in dementia. Longitudinal studies further support the findings and found that reduced CA, elevated GCDCA, elevated secondary BAs (glycoursodeoxycholic acid, lithocholic acid (LCA), glycolithocholic acid, and glycodeoxycholic acid (GDCA), and ratios of GDCA: CA, taurodeoxycholic acid: CA correlate with an increased risk of dementia. In addition, CA, chenodeoxycholic acid, allocholic acid, and LCA may be of significance in distinguishing AD patients from healthy people. Multiple evidence showed that reduced CA (primary BAs) level and elevated conjugated or secondary BAs levels are linked to a higher risk of dementia. Bile acids play a complex role in the pathogenesis of dementia.

Indexed as

Bile Acids and SaltsDementiaCross-Sectional StudiesHumansLongitudinal StudiesBile Acids and SaltsAlzheimer’s diseaseBile acidsCognitive impairmentDementia

Identifiers

PMID40699484
PMCPMC13356254

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.