Evidence map›Paper›PMID 40699773›Full record

ReviewCurrent issues in molecular biology2025

The Impact and Molecular Mechanisms of Exercise in Cancer Therapy.

Yingjie Sun, Yixiao Ma, Lei Shi, Tong Liu, Yahong Dong, Qiguan Jin

Registry-linked trialAbstract readReview
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07453173 (A Pilot, Single-Arm, Prospective Study Assessing Feasibility and Safety of a Supervised Progressive Resistance Training Program During Total NeoadjuvantTherapy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07453173 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot, Single-Arm, Prospective Study Assessing Feasibility and Safety of a Supervised Progressive Resistance Training Program During Total NeoadjuvantTherapy (RAPIDO) Until Surgery in Locally Advanced Rectal Cancer

TypeinterventionalSponsorFundacion Arturo Lopez PerezRan2026 to 2027Enrolled15ConditionsLocally Advanced Rectal CancerArmsStrength training program
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
  4. Molecular Biology: Navigating the Landscape.Current issues in molecular biology · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yingjie SunCollege of Physical Education, Yangzhou University, Yangzhou 225009, China.ORCID 0009-0003-6128-5847
Yixiao MaCollege of Physical Education, Yangzhou University, Yangzhou 225009, China.
Lei ShiCollege of Physical Education, Yangzhou University, Yangzhou 225009, China.
Tong LiuCollege of Physical Education, Yangzhou University, Yangzhou 225009, China.
Yahong DongCollege of Physical Education, Yangzhou University, Yangzhou 225009, China.
Qiguan JinCollege of Physical Education, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-5539-8779

Funding

Postgraduate Research & Practice Innovation Program of Jiangsu Province in China KYCX24_3731the National Key Research and Development project in China 2016YFD0400603
6 · The paper itself

Abstract

Cancer is a major global health issue, and exercise has become a key supportive treatment. It contributes to reducing cancer risk, enhancing prognosis, and aiding recovery, especially for survivors. However, the exact mechanisms, such as how exercise reduces cancer risk or enhances treatment, are still unclear. Current research often focuses on specific cancer types, ignoring the diverse needs of patients. This limits the development of personalized exercise plans. Additionally, there is insufficient comparison of exercise types-like aerobic, resistance, and high-intensity interval training-regarding their adverse effects and long-term benefits. The best combination of exercises and personalized strategies remains unknown. This review underscores the contribution of physical exercise to cancer prevention and treatment, emphasizing its positive effects on reducing fatigue, improving physical strength, and enhancing mental health. It also explores the molecular mechanisms of regulating tumor immunity and energy metabolism. Additionally, the article covers criteria for selecting exercise types and intensities, and the development of personalized exercise plans. Finally, it provides guidelines for exercise prescriptions and suggests future research directions to improve interventions for cancer patients.

Indexed as

cancer patientsexerciseexercise prescriptionphysical activity

Identifiers

PMID40699773
PMCPMC12110539

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.