ArticleCell reports2025
Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Opposing Roles of OPN3 and OPN5 Affecting the Intrinsic Pupillary Light Reflex of the Mammalian Iris.Investigative ophthalmology & visual science · 2026Article
- Effect of Light Wavelength on Corneal Sensitivity.Ophthalmology science · 2026Article
- Non-visual opsins and their role in circadian photoentrainment.Eye and vision (London, England) · 2026Review
- The physiological functions of OPN5m.Eye and vision (London, England) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The cornea is the transparent tissue at the ocular surface that generates most of the refractive power of the eye. Due to its exposed location, the cornea is uniquely in danger of injury. Rapid and efficient healing is required for high-acuity vision. Here, we show that epithelial corneal wounding induces Opn5, an opsin G-protein-coupled receptor (GPCR) sensitive to ultraviolet/violet light, at the cornea's surface in both mice and primates. The expression of corneal Opn5 is coincident with the direct light sensitivity of multiple pathways, including circadian rhythms, damage-response genes, and immune modulators. The presence of a violet-light:dark cycle substantially accelerates epithelial wound closure both in vivo and ex vivo. Corneas lacking Opn5 have markedly impaired wound healing. Violet light also accelerates wound healing in non-human primate corneas and induces gene expression similar to mice. These results demonstrate that corneal wounding induces direct photosensitivity via Opn5, which accelerates wound healing in the cornea.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.