ArticleCell reports2025
Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.
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Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Evolutionary conservation and adaptability of cholecystokinin neuropeptide signaling in the sea cucumber Apostichopus japonicus.BMC biology · 2026Article
- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- A brain-gut excitatory peptide/CCHamide homolog regulates satiation and motivational state transitions in the Aplysia feeding circuit.The Journal of biological chemistry · 2026Article
- Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.Research square · 2026Article
- Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.bioRxiv : the preprint server for biology · 2026Article
- Identification of a G Protein-Coupled Receptor for Buccalin-Type Peptides in the MolluskACS omega · 2025Article
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Authors and funding
35 authors.
Guo ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. Electronic address: zhangguonanda@nju.edu.cn.
Xue-Ying DingState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Elena V RomanovaDepartment of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Cui-Ping LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Michael A BarryDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alisha DodaDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA.
Qian-Xue ChenDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carrie ReaverDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Qing-Chun JinState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Stanislav S RubakhinDepartment of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Fan LiState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Yu-Fei JinState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Yan-Sheng KanState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Yu-Ling LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Shi-Qi GuoState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Ying-Yu XueState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Yu-Shuo MeiState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Ping FuState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Ju-Ping XuState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Rui-Ting MaoState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Cheng-Yi LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Yan-Chu-Fei ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Yi-Long ZhangState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Jian-Hui ChangState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Shao-Qian WuState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Hui-Ying WangState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Wei-Jia LiuState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Ping ChenState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Zhen ZhouState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.
Hai-Bo ZhouSchool of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu, China; Peng Cheng Laboratory, Shenzhen, China. Electronic address: haibozhou@nju.edu.cn.
Quan YuPeng Cheng Laboratory, Shenzhen, China. Electronic address: yuq@pcl.ac.cn.
James W CheccoDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA; The Nebraska Center for Integrated Biomolecular Communication (NCIBC), University of Nebraska-Lincoln, Lincoln, NE, USA.
Jonathan V SweedlerDepartment of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Elizabeth C CropperDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jian JingState Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Peng Cheng Laboratory, Shenzhen, China. Electronic address: jingj01@live.com.
Funding
The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9MSUBCELLULAR CHARACTERIZATION OF NEUROTRANSMITTERSR01NS031609 · NINDS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI SWEEDLER, JONATHAN V. · 1998 to 2022
$6.2MNeural Basis of Behavioral ArousalR01NS066587 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CROPPER, ELIZABETH C · 2009 to 2023
$5.2MA novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop systemRF1NS118606 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H, CHESTEK, CYNTHIA ANNE · 2020 to 2020
$3.0MA novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop systemR01NS118606 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H, CHESTEK, CYNTHIA ANNE · 2023 to 2024
$1.7MNIDA NIH HHS P30 DA018310NINDS NIH HHS R01 NS031609NINDS NIH HHS R01 NS066587NINDS NIH HHS R01 NS118606NINDS NIH HHS RF1 NS118606
Abstract
Transitions from hunger to satiety involve multiple behavioral changes, including modulation and inhibition of feeding behavior. In mammals, cholecystokinin (CCK) is a key satiety peptide implicated in these processes; however, whether and how CCK might induce satiety via synaptic and intrinsic plasticity remains unclear. Here, we investigate CCK-type signaling in the protostome mollusk Aplysia californica. We demonstrate that Aplysia CCK (apCCK) acts as a conserved brain-gut peptide. Gut-localized apCCK-expressing neurons project centrally and release apCCK near the feeding-pattern generator. In vivo, apCCK suppresses food intake, while in vitro, it shifts motor output toward egestive patterns and inhibits feeding programs. Mechanistically, apCCK modulates the excitability of the egestive-promoting B20 interneuron and suppresses synaptic input to protraction-phase motoneurons, thereby altering program selection and inhibiting feeding-program generation. These findings highlight the importance of both synaptic and intrinsic plasticity in specific circuit elements for implementing motivational shifts driven by satiety signaling.
Indexed as
AplysiaCholecystokininMotivationNeuronal PlasticitySignal TransductionSynapsesAnimalsFeeding BehaviorInterneuronsMotor NeuronsCholecystokininAplysiacholecystokininCP: MetabolismCP: Neuroscienceintrinsic plasticitymotivational shiftsatiety peptidesynaptic plasticitytrapped ion mobility mass spectrometry
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