Evidence map›Paper›PMID 40700152›Full record

ReviewJournal of xenobiotics2025

Impacts of Metals on Infectious Diseases in Wildlife and Zoonotic Spillover.

Joel Henrique Ellwanger, Marina Ziliotto, José Artur Bogo Chies

Abstract readReview
In one paragraph

Review in Journal of xenobiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joel Henrique EllwangerLaboratory of Immunobiology and Immunogenetics, Postgraduate Program in Genetics and Molecular Biology (PPGBM), Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Rio Grande do Sul, Brazil.ORCID 0000-0002-1040-2738
Marina ZiliottoLaboratory of Immunobiology and Immunogenetics, Postgraduate Program in Genetics and Molecular Biology (PPGBM), Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Rio Grande do Sul, Brazil.ORCID 0000-0001-6129-7934
José Artur Bogo ChiesLaboratory of Immunobiology and Immunogenetics, Postgraduate Program in Genetics and Molecular Biology (PPGBM), Department of Genetics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Rio Grande do Sul, Brazil.ORCID 0000-0001-7025-0660

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior postoctoral fellowship, Programa Institucional de Pós-DoutoradoFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul Programa Pesquisado GaúchoNational Council for Scientific and Technological Development Bolsa de Produtividade em Pesquisa, nível 1ANational Council for Scientific and Technological Development doctoral fellowship
6 · The paper itself

Abstract

Climate change, mining activities, pollution and other human impacts on the natural environment cause significant changes in the concentrations and mixtures of metallic elements found in different ecosystems. Metals such as cadmium, copper, lead and mercury affect multiple aspects of host-pathogen interactions, influencing the risk of infectious diseases caused by various classes of pathogens. Notably, exposure to metals in doses and combinations toxic to the immune system can favor the dissemination of pathogens in natural environments, threatening the reproduction, well-being and survival of varied animal species. However, these problems remain neglected, since the influences of metals on infectious diseases are studied with a primary focus on human medicine. Therefore, this article aims to review the influence of metals/metalloids (e.g., arsenic, cadmium, chromium, copper, iron, lead, mercury, nickel, zinc) on infectious and parasitic diseases in animals living in natural environments. The potential impact of metals on the risk of zoonotic spillover events is also discussed. Metal pollution tends to increase as the demand for elements used in the manufacture of industrial products, batteries, and electronic devices increases globally. This problem can aggravate the biodiversity crisis and facilitate the emergence of infectious diseases. Considering the interconnections between pollution and immunity, measures to limit metal pollution are necessary to protect human health and biodiversity from the risks posed by pathogens. This review helps fill the gap in the literature regarding the connections between metal pollution and various aspects of infectious diseases.

Indexed as

disease ecologyecoimmunologyimmunologyinfectious diseasesmetalsnutritional ecologyparasitologypollutiontoxicologywildlife

Identifiers

PMID40700152
PMCPMC12285991

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.