Evidence map›Paper›PMID 40702006›Full record

ArticleNature communications2025

Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3B

Maria Helena Bortolozzo-Gleich, Guillaume Bouisset, Lan Geng, Antonia Ruiz Pino, Yuki Nomura, Shuting Han, Yulong Li, Félix Leroy

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Tail-rattling in rodents: more than a threat display.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Helena Bortolozzo-GleichInstituto de Neurociencias CSIC-UMH, Avenida Santiago Ramon y Cajal, San Juan, de Alicante, Spain.
Guillaume BouissetInstituto de Neurociencias CSIC-UMH, Avenida Santiago Ramon y Cajal, San Juan, de Alicante, Spain.ORCID http://orcid.org/0009-0003-7168-0453
Lan GengState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.
Antonia Ruiz PinoInstituto de Neurociencias CSIC-UMH, Avenida Santiago Ramon y Cajal, San Juan, de Alicante, Spain.ORCID http://orcid.org/0009-0000-1280-0089
Yuki NomuraInstituto de Neurociencias CSIC-UMH, Avenida Santiago Ramon y Cajal, San Juan, de Alicante, Spain.ORCID http://orcid.org/0000-0003-0192-8882
Shuting HanBrain Research Institute, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-9315-3089
Yulong LiState Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-9166-9919
Félix LeroyInstituto de Neurociencias CSIC-UMH, Avenida Santiago Ramon y Cajal, San Juan, de Alicante, Spain. felxfel@aol.com.ORCID http://orcid.org/0000-0003-1715-3233

Funding

Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6M
NINDS NIH HHS U01 NS120824Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) PZ00P3_216312
6 · The paper itself

Abstract

The neuropeptide arginine-vasopressin (AVP) has been repeatedly associated with the autism spectrum disorder (ASD) but the underlying mechanisms remain unclear. As Shank3B

Indexed as

Arginine VasopressinAutism Spectrum DisorderNerve Tissue ProteinsSeptal NucleiSocial BehaviorVasopressinsAggressionAnimalsBehavior, AnimalDisease Models, AnimalMaleMiceMice, Inbred C57BLMicrofilament ProteinsReceptors, VasopressinArginine VasopressinMicrofilament ProteinsNerve Tissue ProteinsReceptors, VasopressinShank3 protein, mouseVasopressins

Identifiers

PMID40702006
PMCPMC12287534

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.