ArticleNature2025
A gut sense for a microbial pattern regulates feeding.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Dysregulated eating behaviour and microbiota-based interventions targeting eating disorders and food addiction.Gut microbes · 2026Review
- The importance of cross-talk in research and the body: An early career researcher perspective.Experimental physiology · 2026Article
- Enteroendocrine cells wire the gut-brain vagal axis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Vagal neuropathies: An underrecognized potential driver of physical, mental, and immune symptoms.Brain, behavior, & immunity - health · 2026Review
- Macrophages Intracellularly Gelated With Bioactive Hydrogels for Synergistic Neutralization, Eradication, and Osteopromotion in Periodontitis Treatment.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Gut distension evokes rapid neural dynamics in vagal and hindbrain populations of larval zebrafish.iScience · 2026Article
- TTX-S/TTX-R NaActa physiologica (Oxford, England) · 2026Article
- Mechanisms and clinical implications of gut-brain interactions.The Journal of clinical investigation · 2026Review
- Gut Microbiota-Mediated Mechanisms of Traditional Chinese Medicine in Obesity Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- A taxon-centered review of bacterial shifts in psychiatric disorders.Frontiers in psychiatry · 2026Review
- The gut microbiota-enteric nervous system axis: from bidirectional programming to precision therapeutics in digestive diseases.Frontiers in cellular and infection microbiology · 2026Review
- The Gut-Brain Axis-From Science to Clinical Practice.Gastro hep advances · 2026Review
- Therapeutic potential of modulating endogenous PYY expression for controlling overweight and obesity: a narrative review.Frontiers in nutrition · 2026Review
- More than Dysbiosis: Imbalance in Humoral and Neuronal Bidirectional Crosstalk Between Gut and Brain in Alzheimer's Disease.International journal of molecular sciences · 2025Review
- A neurobiotic sense curbs feeding: a new frontier in gut-brain communication.Nature reviews. Gastroenterology & hepatology · 2025Article
- Exploring the Animal Models of Gastrointestinal and Emotional Comorbidity.Brain and behavior · 2025Review
- The ancient dialogue between brain and body.Current biology : CB · 2025Article
- Adaptive Responses in Severe Acute Malnutrition: Endocrinology, Metabolomics, Mortality, and Growth.Nutrients · 2025Review
- Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Winston W Liu *Laboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Naama Reicher *Laboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Emily Alway *Laboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.ORCID 0000-0003-2524-7539
Laura E RupprechtLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Peter WengLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Chloe SchaefgenLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.ORCID 0009-0005-1897-8423
Marguerita E KleinLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.ORCID 0000-0003-0351-2661
Jorge A VillalobosLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.ORCID 0000-0002-1674-6232
Carlos Puerto-HernandezLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Yolanda Graciela Kiesling AltúnLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Amanda CarbajalLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.ORCID 0000-0001-5939-6597
José Alfredo Aguayo-GuerreroLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.
Alam CossLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA.ORCID 0000-0002-3727-0720
Atharva SahasrabudheResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Polina AnikeevaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-6495-5197
Alan de AraujoMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID 0000-0003-2656-4077
Avnika BaliMonell Chemical Senses Center, Philadelphia, PA, USA.
Guillaume de LartigueMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID 0000-0002-0032-8810
Elvi Gil-LievanaLaboratory Neurobiology of Appetite, Department of Pharmacology, CINVESTAV, Mexico City, Mexico.
Ranier GutierrezLaboratory Neurobiology of Appetite, Department of Pharmacology, CINVESTAV, Mexico City, Mexico.ORCID 0000-0002-9688-0289
Edward A MiaoDepartment of Integrative Immunobiology, Duke University, Durham, NC, USA.ORCID 0000-0001-7295-3490
John F RawlsDepartment of Medicine, Duke University, Durham, NC, USA.ORCID 0000-0002-5976-5206
M Maya KaelbererLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA. mkaelberer@arizona.edu.ORCID 0000-0001-7327-2777
Diego V BohórquezLaboratory of Gut Brain Neurobiology, Duke University, Durham, NC, USA. diego.bohorquez@duke.edu.ORCID 0000-0003-3434-2212
Funding
INTERDISCIPLINARY TRAINING IN THE CHEMICAL SENSEST32DC000014 · NIDCD · MONELL CHEMICAL SENSES CENTER · 1989 to 2025
$1.7MMedical Scientist Training Program Training GrantT32GM145449 · DUKE UNIVERSITY · 2025 to 2025
$1.3MEvaluating the therapeutic potential of vagal CART circuitry for treating metabolic diseaseR01DK116004 · NIDDK · UNIVERSITY OF FLORIDA · 2022 to 2025
$1.2MBacteria sensory transduction from gut to brain to modulate behaviorR01DK132070 · DUKE UNIVERSITY · 2025 to 2025
$410kGlutamatergic neurotransmission in gut neuropod cellsR01DK131112 · DUKE UNIVERSITY · 2025 to 2025
$397kEfferent vagal modulation of neuropod cells in the small intestineK01DK131403 · UNIVERSITY OF ARIZONA · 2025 to 2025
$155kGut epithelial control of nutrient rewardK01DK138286 · DUKE UNIVERSITY · 2025 to 2025
$132kSensing Dietary Amino Acids from Gut to BrainF30DK127650 · NIDDK · DUKE UNIVERSITY · PI Peter Weng · 2022 to 2023
$97kF32 - Bitter chemosensation from gut to brainF32DK139628 · DUKE UNIVERSITY · 2025 to 2025
$81kRapid sugar sensing from gut to brainF30DK136229 · DUKE UNIVERSITY · 2025 to 2025
$55kNCCIH NIH HHS R21 AT010818NIDCD NIH HHS T32 DC000014NIDDK NIH HHS F30 DK122712NIDDK NIH HHS F30 DK127650NIDDK NIH HHS F30 DK136229NIDDK NIH HHS F32 DK127757NIDDK NIH HHS F32 DK139628NIDDK NIH HHS K01 DK131403NIDDK NIH HHS K01 DK138286NIDDK NIH HHS R01 DK116004NIDDK NIH HHS R01 DK131112NIDDK NIH HHS R01 DK132070NIDDK NIH HHS R03 DK114500NIGMS NIH HHS T32 GM145449NIMH NIH HHS DP2 MH122402
Abstract
To coexist with its resident microorganisms, the host must have a sense to adjust its behaviour in response to them. In the intestine, a sense for nutrients transduced to the brain through neuroepithelial circuits guides appetitive choices
Indexed as
ColonFeeding BehaviorFlagellinGastrointestinal MicrobiomeAnimalsBrainFemaleMaleMiceMice, Inbred C57BLNeuronsPeptide YYToll-Like Receptor 5Vagus NerveFlagellinPeptide YYTlr5 protein, mouseToll-Like Receptor 5
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.