SynthesisAnnals of surgical oncology2025
Primary Breast Implant-Associated Squamous Cell Carcinoma: A Proposal for a Better Surgical Approach and Clinical Staging System Based on Tumour Characteristics.
Synthesis in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hot Topics in Implant-Based Breast Reconstruction.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe literature on squamous cell carcinoma associated with breast implants (BIA-SCC) is scarce and is limited primarily to case reports, nonsystematic and systematic reviews. There is no standard for diagnosis, staging, surgical treatment, or survival analysis.
methodsWe add to the literature the first case of BIA-SCC in Brazil. We also conducted a systematic review of the literature on BIA-SCC and subsequently proposed a clinical/surgical staging system based on disease-free survival (DFS) and overall survival (OS). The new staging system considers not only local invasion but also capsule rupture during surgery and the type of resection.
resultsSurvival and recurrence were evaluated in 17 patients. Nine patients experienced recurrence (mean 5.2 months; range 1-12 months), and six died (mean 8.2 months; range 2-17 months). The three patients who experienced prolonged survival underwent capsule resection, mastectomy, and chest wall resection, and one patient underwent capsulectomy despite the absence of extracapsular extension of the disease. The mean OS was 15.5 months (range 2-96 months), and the mean DFS was 13.5 months (range 0-96 months). The new clinical/surgical staging system had good prognostic value for OS (p < 0.001) and DFS (p < 0.001).
conclusionsSquamous cell carcinoma associated with breast implants has a poor prognosis, making early preoperative diagnosis crucial. Total capsulectomy, without spillage of the contents of the capsule, followed by resection of adjacent tissue, may prevent local recurrence. In clinical-surgical staging, the surgeon should consider not only capsule infiltration but also the possibility of surgical injury and the type of resection.
Indexed as
Identifiers
40702198What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.