ArticleEuropean journal of medical research2025
Dynamic alterations and clinical implications of the plasma proteome in pediatric sepsis.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biomimetic Targeted Drug Delivery for Liver Failure in Abdominal Sepsis: Focus on Autologous Erythrocyte Ghosts.International journal of molecular sciences · 2026Review
- Development and validation of QuadraSynth ML: a novel classifier for sepsis prediction.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundCurrent sepsis biomarkers have limitations, but mass spectrometry-based proteomics can identify patients at high risk of mortality or organ dysfunction, identify the molecular mechanisms of pediatric sepsis, and reveal personalized biomarkers and therapeutic strategies, with high-risk cohorts benefiting from early and accurate identification through clinical biomarkers.
methodsThe young mice were randomly divided into sepsis and sham groups(D0), and then the plasma was dissected at D0, Day 1(D1), Day 3(D3), and Day 7(D7) after surgery for additional protein identification by liquid chromatography-mass spectrometry (LC/MS) proteomics. Subsequently, data from 66 cases of children diagnosed with sepsis upon admission to Pediatric Intensive Care Unit at Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University were gathered. Dynamic plasma samples (D1, D3, D7) were obtained for ELISA verification and correlation analysis of the candidate biomarkers to determine the clinical significance of sepsis candidate plasma biomarkers.
resultsAmong the 6578 proteins identified, the septic mice groups (D1, D3, D7) demonstrated 161 differently upregulated plasma proteins. The main enriched pathways in the KEGG study were related to complement and coagulation cascades, focal adhesion, and phagosomes. ELISA test results indicated that among pediatric patients, the five candidate biomarkers (AT III, CFD, Col1α1, EGFR, Thbs1) all showed varying degrees of decrease in diagnosing sepsis. Correlation study results suggested that AT III was adversely linked with IgA, IgG, IgM, C3, with Pearson's coefficients of -0.543, -0.217, -0.526, -0.128, respectively. CFD was positively connected with IgA, IgG, IgM, and negatively correlated with C3. Col1α1, CFD, EGFR, and Thbs1 demonstrated negative correlation with suppressive CD8 + cells, while Col1α1, EGFR, and Thbs1 showed positive correlation with B cells (CD19 +). Furthermore, Col1α1, CFD, EGFR, and Thbs1 revealed positive connection with CD4 + /CD8 + . Additionally, AT III demonstrated positive connection with PT, APTT, INR, D-Dimer, and Fbg. Conversely, Col1α1 and EGFR showed negative association with PT, APTT, INR, D-Dimer, and Fbg. CFD was positively correlated with Fbg, and Thbs1 showed positive correlation with D-Dimer.
conclusionWithin 1 week of sepsis onset, 161 proteins revealed alterations in young mice, with the complement and coagulation cascades, focal adhesion, and phagosome pathways showing the most significant correlations. All prospective markers reduced following the recognition of sepsis and were associated with coagulation and immunological function in pediatric patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.