ArticleRenal failure2025
Association between circulating Klotho levels and hypertension: insights from NHANES, Mendelian randomization, and an Asian cohort.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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6 authors.
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Abstract
backgroundKlotho has been implicated in blood pressure regulation through its effects on vascular integrity, calcium-phosphate homeostasis, and oxidative stress pathways. However, population-level data exploring its association with hypertension remain inconclusive.
methodsData from the U.S. National Health and Nutrition Examination Survey (NHANES; 2007-2016) were analyzed using weighted multivariate generalized linear regression models. Klotho levels were evaluated as both continuous and categorical (quartiles) variables. A nonlinear dose-response relationship was further explored using spline regression. To assess potential causality, a two-sample Mendelian randomization (MR) analysis was conducted using the inverse-variance weighted (IVW) method. External validation was performed in an independent Asian cohort.
resultsIn NHANES, no statistically significant association was observed between serum Klotho and hypertension, either as a continuous variable or by quartiles after adjusting for coronary heart disease (CHD) or hyperlipidemia (e.g. Q4: OR = 0.89 [95% CI: 0.79-1.00],
conclusionAcross three distinct populations, no robust linear or causal relationship between Klotho levels and hypertension was identified. However, due to the limited sample size of the Asian cohort, future studies are warranted to validate these findings in larger populations.
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