ArticleJournal of leukocyte biology2025
Mechanisms of immune suppression in sepsis/shock: one investigator's/lab group's experience (SLB 2024 legacy award presentation).
Article in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Endothelial cell, but not neutrophil, programmed cell death receptor-ligand 1 loss has a morbid impact on experimental murine shock/sepsis-induced lung injury.Frontiers in immunology · 2026Article
- Differential Effects of Endothelial Cell- as opposed to Neutrophil-Lineage Restricted PD-L1 Gene Expression on Experimental Murine Shock/ Sepsis-Induced Lung Injury.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
When I think about scientific/professional "legacy," for me there are at least 3 areas to consider: 1) the actual scientific legacy you (and your lab members) have contributed to, 2) the people you have touched and how they touch you in this scientific journey, and 3) what professional impact you left on the scientific/academic community. So, with that in mind, I will try to share my (our lab groups') story relative to our contributions to the delineation of various mechanisms that appear to contribute to the development of immune suppression and/or organ injury resultant from shock and/or septic insult by weaving in and out of the science over the past ∼35 yr, while digressing from the pure science at certain places in hope of giving you some personal/professional context that effected this individual's (lab groups') scientific journey. Inasmuch, please appreciate that the science discussed will be more of a summary of the contributions we think we may have made (appreciating as possible the contributions of colleagues in the field that spoke to such findings) relative to the understanding of the mechanisms of immune suppression in shock/sepsis and will not be a deep dive into the specific data sets.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.