Evidence map›Paper›PMID 40703123›Full record

ArticleEuropean heart journal. Digital health2025

Ultra-short-term heart rate variability using a photoplethysmography-based smartphone application: a TeleCheck-AF subanalysis.

Henrike Aenne Katrin Hillmann, Astrid N L Hermans, Monika Gawalko, Johanna Mueller-Leisse, Konstanze Betz, Afzal Sohaib, Chi Ho Fung, Ron Pisters, Piotr Lodziński, Sevasti-Maria Chaldoupi and 17 more

Abstract read
In one paragraph

Article in European heart journal. Digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Henrike Aenne Katrin HillmannHannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Astrid N L HermansDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0002-9034-1479
Monika GawalkoDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0003-4619-9062
Johanna Mueller-LeisseHannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-3485-7657
Konstanze BetzDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0002-3943-3896
Afzal SohaibBarts Heart Center, St Bartholomew's Hospital, London, United Kingdom.ORCID https://orcid.org/0000-0002-2946-2343
Chi Ho FungDepartment of Cardiology, King George Hospital, Ilford, United Kingdom.ORCID https://orcid.org/0000-0002-5944-5878
Ron PistersDepartment of Cardiology, Rijnstate Hospital, Arnhem, The  Netherlands.ORCID https://orcid.org/0000-0001-8965-0664
Piotr Lodziński1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
Sevasti-Maria ChaldoupiDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0003-3938-6193
Dhiraj GuptaDepartment of Cardiology, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0002-3490-090X
Rachel M J van der VeldenDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.
Nikki A H A PluymaekersDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0002-9663-6315
Emma SandgrenDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0001-7410-3246
Malene NørregaardDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.ORCID https://orcid.org/0009-0004-1227-5113
Stijn EvensQompium NV, Kempische Steenweg 293/16, 3500 Hasselt, Belgium.
Thomas De CoomanQompium NV, Kempische Steenweg 293/16, 3500 Hasselt, Belgium.
Dominique VerhaertDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0003-3477-2589
Martin HemelsDepartment of Cardiology, Rijnstate Hospital, Arnhem, The  Netherlands.ORCID https://orcid.org/0000-0002-2373-9858
Arian SultanDepartment of Electrophysiology, University of Cologne, Heart Center, Cologne, Germany.
Daniel StevenDepartment of Electrophysiology, University of Cologne, Heart Center, Cologne, Germany.ORCID https://orcid.org/0000-0001-6839-5895
Henry GruwezDepartment of Cardiology, Hospital East-Limburg, Genk, Belgium.
Jeroen M HendriksDepartment of Nursing, Maastricht University Medical Centre, Maastricht, The Netherlands.
Daniel ScherrDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0001-5868-5493
Martin ManningerDivision of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.ORCID https://orcid.org/0000-0002-0545-4373
Dominik LinzDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER Maastricht, The  Netherlands.ORCID https://orcid.org/0000-0003-4893-0824
David DunckerHannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0003-2996-6338

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Autonomic nervous system activation plays an important role in the pathophysiology of atrial fibrillation (AF). It can be determined using heart rate variability (HRV). We aimed to evaluate the feasibility of using photoplethysmography (PPG) recordings for the assessment of the ultra-short-term HRV. Methods and results: TeleCheck-AF is a structured mobile health approach, comprising the on-demand use of a PPG-based smartphone application prior to a scheduled teleconsultation to ensure comprehensive remote AF management. Participants with at least one PPG recording in sinus rhythm were included to assess resting heart rate, root mean square of successive differences (RMSSD), patient compliance and data consistency. In total, 855 patients [39.4% women] with 13 465 recordings were included. Patient compliance was 95.2% (IQR 76.2-114.3%). Median heart rate per patient was 66.5 (IQR 60.0-74.0) b.p.m., median RMSSD per patient was 40 (IQR 33-50) ms and median recording consistency was ±5.2 (IQR 3.8-7.0) b.p.m. and ±14.8 (IQR 9.3-21.1) ms, respectively. RMSSD was lower in men than women, in patients with CHA Conclusion: The ultra-short-term HRV can be determined in 1-min PPG recordings with high user compliance and high inter-recording consistency within a structured mobile health AF management approach. The strategy used in this study may also be feasible for the management of other conditions in which the HRV plays a role for diagnostics and therapy.

Indexed as

Atrial fibrillationDigital devicesHeart rate variabilityPhotoplethysmographyRemote monitoringTelemonitoring

Identifiers

PMID40703123
PMCPMC12282385

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.