Observational studyFrontiers in public health2025
Association between insecticide exposomics and cognitive function in older adults: an observational study based on NHANES 2011-2014.
Observational study in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Value of lncRNA LINC00641 as a Potential Biomarker for Diagnosis of Alzheimer's Disease and Elucidation of its Underlying Molecular Mechanism.Journal of molecular neuroscience : MN · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to investigate the association between exposure to insecticide exposomics and cognitive function, among adults aged 60 and above. Methods: We employed a multi-stage probability sampling method to analyze data derived from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2014. The study investigated the impact of insecticides exposure on cognitive performance, as measured by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word Learning Test (CERAD-WL), CERAD Delayed Recall Test (CERAD-DR), Animal Fluency Test (ATF), and Digit Symbol Substitution Test (DSST). Logistic regression models were used to evaluate the impact, with adjustments for sociodemographic and lifestyle variables, and subgroup analyses were conducted to further elucidate the findings. Results: A total of 1,544 participants were included after applying strict exclusion criteria. Logistic regression analysis disclosed a significant association between insecticides exposure and the risk of cognitive impairment. Specifically, for CERAD-WL, the unadjusted model showed an Odds Ratio (OR) of 0.68 (95% CI: 0.49-0.93), Conclusion: Our study indicates an association between insecticides exposure and cognitive impairment, particularly affecting memory and delayed recall. Yet, the cross-sectional design prevents conclusive causality claims. Future research should adopt longitudinal approaches, utilize biological markers for precise exposure measurement, and apply advanced statistical techniques to better understand the exposure-outcome relationship. Including a broader age range and detailed confounder data will also strengthen causal inferences. While our findings offer preliminary evidence, more robust studies are necessary to confirm causality and guide preventive measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.