ArticleFrontiers in surgery2025
Real-time monitoring of spinal cord hemodynamics with laser speckle contrast imaging during pedicle subtraction osteotomy in rabbits.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to evaluate the efficacy of Speckle Contrast Imaging (LSCI) in real-time monitoring of spinal cord hemodynamic changes during spinal osteotomy in rabbits and to assess its clinical relevance for intraoperative blood flow management. Methods: Thirty-one healthy male New Zealand white rabbits (clean-grade) were subjected to Pedicle subtraction osteotomy (PSO) under general anesthesia. The spinal cord and posterior vasculature were surgically exposed, and LSCI was employed to quantify blood flow perfusion (Perfusion Units, PU) and posterior spinal artery diameter (μm) at four critical stages: (1) pre-osteotomy (baseline), (2) post-osteotomy, (3) post-osteotomy site compression, and (4) post-dura removal. Results: LSCI successfully captured dynamic hemodynamic changes: Blood flow perfusion decreased significantly from baseline (519.22 ± 137.87 PU) to post-osteotomy (315.00 ± 50.24 PU, Conclusion: LSCI provides reliable, non-invasive real-time monitoring of spinal cord hemodynamics during osteotomy, demonstrating significant perfusion and vascular diameter fluctuations. This technology offers a promising tool for intraoperative spinal cord protection and warrants further clinical translation.
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