Evidence map›Paper›PMID 40703450›Full record

ArticleiScience2025

Primary and metastatic cellular landscapes in human pancreatic cancer.

Nina G Steele, Veerin R Sirihorachai, Ahmed M Elhossiny, Ian M Loveless, Padma Kadiyala, Monica Bonilla, Emily L Lasse-Opsahl, Carinna Solano Vargas, Katelyn L Donahue, Samantha B Kemp and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Nina G SteeleDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Veerin R SirihorachaiCancer Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.
Ahmed M ElhossinyDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Ian M LovelessCenter for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, MI 48202, USA.
Padma KadiyalaDepartment of Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Monica BonillaCancer Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.
Emily L Lasse-OpsahlCancer Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.
Carinna Solano VargasCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.
Katelyn L DonahueCancer Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.
Samantha B KempDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Valerie GunchickDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Yatrik M ShahDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Timothy L FrankelDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Filip BednarDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Arvind RaoDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Benjamin L AllenDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Jiaqi ShiRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Vaibhav SahaiDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Howard C CrawfordDepartment of Surgery, Henry Ford Health Systems, Detroit, MI 48202, USA.
Eileen S CarpenterRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Marina Pasca di MaglianoDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironmentR01CA275182 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Benjamin Allen, Marina Pasca Di Magliano · 2023 to 2026
$2.4M
Defining epigenetic signaling to reshape pancreatic tumor microenvironmentR37CA262209 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jiaqi Shi · 2022 to 2026
$2.3M
BLRD VA IK2 BX005875NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA275182NCI NIH HHS R37 CA262209
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a complex tumor microenvironment (TME). We utilized single cell RNA sequencing to compare the TMEs of metastatic sites and primary tumors. We detected increased prevalence of exhausted CD8

Indexed as

CancerIntegrative aspects of cell biologyTranscriptomics

Identifiers

PMID40703450
PMCPMC12283900

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.