Evidence map›Paper›PMID 40703511›Full record

ReviewFrontiers in immunology2025

Protein regulatory network mediated by palmitoylation modifications in the pathological progression of Parkinson's disease: a narrative review.

Jingjing Liu, Shanshan Wang, Lei Fan, Xin Zhou, Sen Zhang, Qinglu Wang, Panpan Dong, Bo Yu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jingjing LiuGraduate School of Education, Shandong Sport University, Jinan, China.
Shanshan WangDepartment of Neurology, Zibo 148 Hospital, Zibo, Shandong, China.
Lei FanDepartment of Rehabilitation, Liuzhou People's Hospital, Liuzhou, China.
Xin ZhouGraduate School of Education, Shandong Sport University, Jinan, China.
Sen ZhangGraduate School of Education, Shandong Sport University, Jinan, China.
Qinglu WangGraduate School of Education, Shandong Sport University, Jinan, China.
Panpan DongCollege of Basic Medicine, Qilu Medical University, Zibo, Shandong, China.
Bo YuGraduate School of Education, Shandong Sport University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Palmitoylation is a reversible lipid modification regulated by palmitoyl transferases and acyl-protein thioesterases, in which palmitic acid is attached to protein cysteine residues. This modification plays a pivotal role in modulating membrane localization and protein stability, and its dysregulation is closely associated with various neurodegenerative diseases, including Parkinson's disease (PD). In PD, synaptotagmin-11, encoded by the PD risk gene

Indexed as

LipoylationParkinson DiseaseProtein Processing, Post-Translationalalpha-SynucleinAnimalsDisease ProgressionDopaminergic NeuronsHumansSynaptotagminsalpha-SynucleinSynaptotagminsNLRP3 inflammasomepalmitoylationParkinson’s diseasesynaptotagmin-11α-synuclein

Identifiers

PMID40703511
PMCPMC12283271

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.