ArticleNigerian medical journal : journal of the Nigeria Medical Association
Comparison of diagnostic accuracy of ultra-sensitive and conventional rapid diagnostic tests for malaria in asymptomatic pregnant women at a tertiary hospital in North-Central Nigeria.
Article in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Malaria in pregnancy continues to be a major public health problem in sub-Saharan Africa. Pregnant women are at a higher risk because asymptomatic malaria infections may lead to detrimental pregnancy outcomes. Early diagnosis is the main strategy to reduce these adverse outcomes; however, conventional rapid diagnostic tests (RDTs) are inadequate for detecting low-density infections. There are prospects that ultra-or highly sensitive RDTs may improve the detection of malaria in these populations. The objective of this study is to assess and compare the diagnostic accuracy of ultrasensitive and conventional RDTs for malaria in asymptomatic pregnant women at the Benue State University Teaching Hospital, Makurdi. Methodology: This was a cross-sectional comparative study conducted in the antenatal clinic of Benue State University Teaching Hospital, Makurdi, Nigeria. It involved 107 asymptomatic pregnant women whose peripheral venous blood samples were obtained and tested with conventional RDT (co-RDT) and ultra-sensitive RDT (us-RDT) to detect Plasmodium falciparum in peripheral blood. The results from microscopy were used as the reference standard. Results were categorised as positive and negative. Results: The overall prevalence rate of P. falciparum was 14% using microscopy, followed by us-RDT (12.1%) and co-RDT (2.8%). The us-RDT showed a higher sensitivity (66.7% vs. 13.3%), positive predictive value (83.3% vs. 50.0%), negative predictive value (94.7% vs. 87.4%), and test accuracy (93.5% vs. 86.0%) compared to co-RDT. In comparison, the specificity of both tests was similar (97.8%). There was a significant difference in diagnostic performance between the two RDTs (p=0.002). Conclusion: The study suggests that ultrasensitive RDTs are a more effective test for detecting P. falciparum infection in asymptomatic pregnant women compared to conventional RDTs. This may have important implications for clinical decision-making and the management of malaria in pregnancy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.