ArticleEnvironment & health (Washington, D.C.)2025
Evaluating the Vascular Risk of PFCs: An Integrated XGBoost-Driven Structure-Activity Prediction and Experimental Validation Study.
Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Indoor VOCs Exposure Disrupts Hemostatic Balance: Plasma Proteomics Identifies Complement and Coagulation Cascade Dysregulation as a Critical Signature.Environment & health (Washington, D.C.) · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perfluorochemicals (PFCs) are emergent and persistent organic pollutants with widespread application. Their structural similarity and detection in serum raises substantial concerns regarding their toxicological effects. While the endocrine-disrupting effects of PFCs are well-recognized, the structure-activity relationship with respect to vascular function has not been investigated yet. This study addresses this critical gap by investigating the impact of PFCs on endothelial cell function, a key determinant of cardiovascular health. Through a machine learning-based quantitative structure-activity relationship (QSAR) model, we analyzed 16 structural descriptors for 23 environmentally prevalent PFCs with respect to their binding affinities to endothelial cell receptors. The eXtreme Gradient Boosting (XGBoost) algorithm suggested short-chain PFCs with strong acid groups may as particularly detrimental to endothelial cells, a finding substantiated by subsequent cell culture experiments. We also integrated computational and experimental approaches, providing a detailed understanding of the structure-activity and dose-response relationships of PFCs. Furthermore, the population health risk assessment, linking
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