ArticlemicroPublication biology2025
PDLIM3 expression is implicated in the invasive behavior of glioblastoma stem cells and their ability to form neurospheres.
Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
The recurrence of glioblastoma can be attributed to the high invasiveness and resistance of glioblastoma stem cells (GSCs). Therefore, it is crucial to investigate the molecular mechanisms that drive the agressiveness of these cells. This research focuses on the actin-associated protein PDLIM3 that we found overexpressed in GBM and in highly invasive GSCs. Suppressing PDLIM3 expression with targeted siRNAs significantly decreases cell invasion. Additionally, our findings highlight that PDLIM3 is essential for GSCs in forming neurospheres. This research provides the first evidence that PDLIM3 may contribute to the aggressiveness of glioblastoma by facilitating GSCs sphere formation and enhancing their invasiveness.
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