Evidence map›Paper›PMID 40704359›Full record

ReviewStructural heart : the journal of the Heart Team2025

Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women.

Giulia Masiero, Anna Franzone, Valeria Paradies, Nicole Karam, Chiara Fraccaro, Chiara De Biase, Mirvat Alasnag, Giulia Botti, Angelicarosa Cascone, Ana Belen Cid-Alvarez and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Structural heart : the journal of the Heart Team, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Giulia MasieroDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua, Italy.
Anna FranzoneDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Valeria ParadiesDepartment of Cardiology, Maasstad Hospital, Rotterdam, the Netherlands.
Nicole KaramDepartment of Cardiology, European Hospital Georges Pompidou, Paris, France.
Chiara FraccaroDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padua, Italy.
Chiara De BiaseDepartment of Cardiology, Clinique Pasteur, Toulouse, France.
Mirvat AlasnagCardiac Center, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia.
Giulia BottiVita-Salute San Raffaele University, Milan, Italy.
Angelicarosa CasconeVita-Salute San Raffaele University, Milan, Italy.
Ana Belen Cid-AlvarezComplejo Hospitalario Universitario de Santiago de Compostela, CIBERCV.
Tanja K RudolphClinic for General and Interventional Cardiology/Angiology, Heart and Diabetes Center NRW, Bad Oeynhausen, Ruhr-University and University of Bielefeld, Germany.
Marta Kaluzna-Oleksy1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Stephane Manzo-SilbermanInstitute of Cardiology Hôpital Pitié-Salpêtrière (AP-HP), Sorbonne University, ACTION Study Group, Paris, France.
Julinda MehilliMedizinische Klinik I, LAKUMED Hospital Landshut.-Achdorf, Landshut, Germany.
Barbara E StähliDepartment of Cardiology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
Julia GrapsaDepartment of Cardiology, Guys and St Thomas NHS Trust, London, UK.
Kyriakos PanaouUniversity Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Barbara BelliniInterventional Cardiology Unit, IRCCS San Raffaele, Hospital, Milan, Italy.
Joanna J WykrzykowskaUniversity Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Sabine BleizifferDepartment of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.
Helene EltchaninoffDepartment of Cardiology, University of Rouen Normandie, Inserm U1096, CHU Rouen, Rouen, France.
Martine GilardINSERM UMR 1304, University of Brest, Brest, France.
Alaide ChieffoVita-Salute San Raffaele University, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of sex on the baseline characteristics, morphology, and clinical presentation of degenerative aortic stenosis (AS) is well-documented but remains poorly understood. Unlike valve surgery, for which patients have been predominantly male, percutaneous treatment of AS has shown balanced representation of both sexes, with women demonstrating greater benefit from transfemoral aortic valve replacement compared to surgical treatment. This review explores sex-specific differences in the epidemiology, pathophysiology, diagnostic challenges, treatment approaches, and clinical outcomes of degenerative AS. Furthermore, it addresses technical, sex-specific considerations in transfemoral aortic valve replacement, including preprocedural screening, device selection, implantation strategy, and postprocedural management.

Indexed as

Aortic stenosisClinical managementDevice selectionSex differencesTranscatheter aortic valve implantation

Identifiers

PMID40704359
PMCPMC12281272

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.