ArticleJournal of extracellular vesicles2025
Unveiling a Novel Mechanism of Enhanced Secretion, Cargo Loading, and Accelerated Dynamics of Bacterial Extracellular Vesicles Following Antibiotic Exposure.
Article in Journal of extracellular vesicles, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Probiotic extracellular vesicles reprogram macrophage immunometabolism: From gut crosstalk to host health.Gut microbes · 2026Review
- Review
- Selective Protein and Lipid Cargo Sorting into Extracellular Vesicles of Lacticaseibacillus paracasei subsp. paracasei.Probiotics and antimicrobial proteins · 2026Article
- Bacterial extracellular vesicles as emerging biostimulants in plant microbe signaling and stress tolerance.World journal of microbiology & biotechnology · 2026Review
- In Vitro and In Vivo Antibacterial Efficacy of a Ciprofloxacin Delivery System Based onAnimals : an open access journal from MDPI · 2026Article
- Bacterial extracellular vesicles: emerging players in antimicrobial resistance and clinical translation.Molecular biology reports · 2026Review
- Transposon mutant library reveals the complex regulatory network of biofilm formation inBiofilm · 2026Article
- Extracellular Vesicles fromMicroorganisms · 2025Article
- Assessment of the reproducibility of bacterial membrane vesicle isolation and characterization.Extracellular vesicles and circulating nucleic acids · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Antibiotic exposure substantially alters the production mechanisms of bacterial extracellular vesicles (BEVs), which serve as carriers for intercellular exchange of DNA, proteins, and nutrients, yet the underlying mechanisms remain elusive. Here, using Escherichia coli as a model, we uncover how antibiotic exposure enhances BEV secretion, cargo enrichment, and motility. Our results demonstrate that enrofloxacin (ENR) triggers the SOS response, leading to upregulation of the endolysin genes essd-1, rrrd, and rzod, causing peptidoglycan layer damage and promoting modest BEV formation with encapsulated bioactive components such as DNA and proteins. More critically, ENR suppresses ompR, a key regulator in the OmpR/EnvZ two-component system, downregulating the expression of the outer membrane (OM) protein OmpC and its associated Mla-OmpC lipopolysaccharide transport complex. This destabilization of the OM further facilitates BEV formation and cargo encapsulation. The ΔompR mutant in E. coli also exhibits reduced type I fimbriae and enhanced BEV motility, indicating that the OmpR/EnvZ system modulates BEV dynamics via type I fimbriae regulation. These findings reveal a novel mechanism by which E. coli adapts to sub-inhibitory antibiotic stress by modulating BEV formation and motility, with implications for biomedical nanodelivery applications.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.