ArticleOphthalmology and therapy2025
Assessment of Relationship between Neovascularization Type Using Wide Field Optical Coherence Tomography Angiography in Eyes with Proliferative Diabetic Retinopathy.
Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Early-warning predictive model of retinal detachment in high myopia: a comprehensive construction and validation study.BMC ophthalmology · 2026Article
- Ultra-widefield color fundus photography in diabetic retinopathy: from panretinal assessment to multimodal integration.Frontiers in medicine · 2026Review
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Authors and funding
5 authors.
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Abstract
introductionRetinal neovascularization in proliferative diabetic retinopathy (PDR) presents with varying morphology and clinical implications. This study aims to classify retinal neovascularization into subtypes and assess their correlation with ischemic index using widefield optical coherence tomography (OCT) angiography.
methodsThis retrospective observational study included 50 treatment-naïve patients (84 eyes) with PDR who underwent baseline widefield fundus photography (CLARUS 500™) and widefield optical coherence tomography angiography (WF-OCTA; Plex Elite 9000) between January 2022 and June 2024. Quantitative analysis of WF-OCTA images assessed capillary nonperfusion (CNP), ischemic index (ISI), and three neovascularization (NV) subtypes: type 1 NV (flat, intraretinal or subinternal limiting membrane growth), type 2 NV (preretinal proliferation extending into the vitreous), and type 3 NV (a combination of types 1 and 2 features, showing both flat and protruding components). Two clinicians manually delineated capillary nonperfusion (CNP) using ImageJ software. Neovascularization (NV) was classified by subtype and location (posterior versus mid-periphery). Ischemic index (ISI), nonperfusion area, best corrected visual acuity (BCVA), and the need for adjunctive interventions (additional laser or vitreoretinal surgery) were correlated with treatment response to panretinal photocoagulation (PRP).
resultsType 1 neovascularization was most frequent (42.1%), with a mean ischemic index (ISI) of 0.19 ± 0.17. Type 3 neovascularization showed the highest ISI (0.27 ± 0.07) and largest nonperfusion area (36.66 mm
conclusionsWF-OCTA proves valuable in the assessment of disease severity and its extent, along with possible implications on planning the intervention for PDR.
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