Evidence map›Paper›PMID 40705191›Full record

ArticleMolecular biology reports2025

Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism.

Yan Tian, Huilan Su, Yunxi Chen, Xiaomeng Geng, Yafang Zhang, Yu Wang, Wenjie Tang, Weiping Fan, Jianjun Zhou, Youzhen Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan Tian *State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, 200120, Shanghai, P.R. China.
Huilan Su *State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, 200120, Shanghai, P.R. China.
Yunxi ChenState Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, 200120, Shanghai, P.R. China.
Xiaomeng GengDepartment of Neonatology and NICU, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, China.
Yafang ZhangDepartment of Neonatology and NICU, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, China.
Yu WangState Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, 200120, Shanghai, P.R. China.
Wenjie TangState Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, 200120, Shanghai, P.R. China.
Weiping FanDepartment of Microbiology and Immunology, Shanxi Medical University, Taiyuan, 030001, China. weipingf@sxmu.edu.cn.
Jianjun ZhouState Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, 200120, Shanghai, P.R. China. zhoujj_2000@aliyun.com.
Youzhen WeiState Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, 200120, Shanghai, P.R. China. wei-youzhen@163.com.

Funding

Key Discipline Construction Project of Shanghai Pudong New Area Health Commission PWZxk2022-20Small and Micro Science and Technology Project of National Health Commission 20004
6 · The paper itself

Abstract

backgroundNephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose-limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H

methodsA cisplatin-induced AKI mouse model was established with or without H₂ administration. Kidney injury biomarkers were evaluated, and levels of inflammation and apoptosis were assessed using TUNEL staining, ELISA, and immunohistochemistry. To investigate the underlying mechanisms, RNA sequencing was performed, followed by heatmap, Venn diagram, and volcano plot analyses to identify differentially expressed genes. KEGG pathway enrichment analysis was used to explore metabolic alterations upon H

resultsH

conclusionMolecular hydrogen confers protection against cisplatin-induced nephrotoxicity by modulating β-HOB metabolism through upregulation of HMGCS2, thereby suppressing renal inflammation and apoptosis. These findings provide new insights into the metabolic mechanism underlying H

Indexed as

3-Hydroxybutyric AcidAcute Kidney InjuryCisplatinHydrogenAnimalsAntineoplastic AgentsApoptosisDisease Models, AnimalInflammationKidneyMaleMiceMice, Inbred C57BL3-Hydroxybutyric AcidAntineoplastic AgentsCisplatinHydrogenApoptosisCisplatinHydrogenInflammationNephrotoxicityΒ-hydroxybutyrate

Identifiers

PMID40705191
PMCPMC12289799

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.