Evidence map›Paper›PMID 40705244›Full record

ArticleDigestive diseases and sciences2025

Tumor Size Does Not Affect Survival Outcomes of Patients Undergoing Resection for a Single Hepatocellular Carcinoma Without Microscopic Vascular Invasion in the Modern Era of Antiviral Therapy.

Yi-Hao Yen, Fang-Ying Kuo, Hock-Liew Eng, Yueh-Wei Liu, Chee-Chien Yong, Chih-Chi Wang, Wei-Feng Li, Chih-Yun Lin

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yi-Hao Yen *Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan. cassell@cgmh.org.tw.
Fang-Ying KuoDepartment of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Hock-Liew EngDepartment of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Yueh-Wei LiuLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chee-Chien YongLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chih-Chi Wang *Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan. ufel4996@ms26.hinet.net.
Wei-Feng LiLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chih-Yun LinBiostatistics Center of Kaohsiung Chang, Gung Memorial Hospital, Kaohsiung, Taiwan.

Funding

Kaohsiung Chang Gung Memorial Hospital CORPG8N0271, CMRPG8L0181, CMRPG8L0182
6 · The paper itself

Abstract

purposeWhether tumor size affects the survival of patients undergoing liver resection (LR) for a single hepatocellular carcinoma (HCC) without microscopic vascular invasion (MVI), i.e., pathological T1N0M0, is controversial.

methodsWe enrolled 626 patients with HCC of pathological stage T1N0M0 of the 7th edition of American Joint Committee on Cancer staging who underwent LR between 2011 and 2021 at our institution. The overall survival (OS) and recurrence-free survival (RFS) of patients with T1N0M0 HCC > 5.0 cm and those with T1N0M0 HCC ≤ 5.0 cm was compared using the Kaplan-Meier estimator and log-rank test both before and after propensity score matching (PSM).

resultsNinety-two (14.7%) patients had T1N0M0 HCC > 5.0 cm. The proportion of patients with cirrhosis was lower in the T1N0M0 HCC > 5.0 cm group than in the T1N0M0 HCC ≤ 5.0 cm group (16.3 vs 41.2%, p < 0.001). Five-year OS did not differ significantly between the two groups before PSM (82 vs 84%, p = 0.857) or after PSM (84 vs 94%, p = 0.678). Five-year RFS did not differ significantly between the two groups before PSM (63 vs. 66%, p = 0.778) or after PSM (65 vs. 65%, p = 0.371).

conclusionTumor size did not affect the survival outcomes of patients undergoing LR for T1N0M0 HCC.

Indexed as

Antiviral AgentsCarcinoma, HepatocellularHepatectomyLiver NeoplasmsTumor BurdenAgedFemaleHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingRetrospective StudiesSurvival RateTreatment OutcomeAntiviral AgentsAntiviral therapyHepatocellular carcinomaLiver resectionMicroscopic vascular invasionOverall survivalRecurrence-free survival

Identifiers

PMID40705244

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.