Evidence map›Paper›PMID 40706290›Full record

ArticleRedox biology2025

15-Lipoxygenase-dependent radiomitigation by NO

Yulia Y Tyurina, Hua Tian, Haider H Dar, Mert Akdogan, Ecem Saritas, Vladimir A Tyurin, Louis J Sparvero, Alexander A Kapralov, Galina Shurin, Renee Fisher and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yulia Y TyurinaDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Hua TianDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Haider H DarDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Mert AkdoganDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Ecem SaritasDepartment of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Vladimir A TyurinDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Louis J SparveroDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Alexander A KapralovDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Galina ShurinDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA.
Renee FisherDepartment of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Michael W EpperlyDepartment of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Kunal SinghDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.
Yuri L BunimovichDepartment of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Joel S GreenbergerDepartment of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Valerian E KaganDepartment of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA, 15219, USA; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15219, USA. Electronic address: kagan@pitt.edu.
Hülya BayirDepartment of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA. Electronic address: hb2753@cumc.columbia.edu.

Funding

Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingR01NS076511 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir, Valerian E Kagan · 2012 to 2026
$6.8M
Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos PyroptosisU01AI156923 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2020 to 2024
$2.4M
Selective Inhibitors of Pro-Ferroptotic Lipoxygenases - Next Generation RadiomitigatorsU01AI156924 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAGAN, VALERIAN E · 2020 to 2024
$2.3M
NIAID NIH HHS U01 AI156923NIAID NIH HHS U01 AI156924NINDS NIH HHS R01 NS076511
6 · The paper itself

Abstract

Threats of irradiation (IR) exposure increase the need for radiomitigators. An important contributor to radiation injury is ferroptosis, triggered by the disbalanced redox metabolism. We showed that 15-lipoxygenase (15-LOX) catalyzed peroxidation of arachidonoyl-phosphatidyl-ethanolamine is an essential ferroptotic response of ileum to total body IR (TBI). Given that nitric oxide (NO

Indexed as

Arachidonate 15-LipoxygenaseFerroptosisIntestinal MucosaNitric Oxide DonorsAnimalsChromatography, LiquidHumansLipid PeroxidationLiquid Chromatography-Mass SpectrometryMaleMass SpectrometryMiceMice, Inbred C57BLMultiomicsNitric OxideOxidation-ReductionArachidonate 15-LipoxygenaseNitric OxideNitric Oxide DonorsGCIB-multiomics/ SIMS imaging of lipids and metabolitesLipid peroxidationNO donorsRadiomitigationTotal body Irradiation

Identifiers

PMID40706290
PMCPMC12309946

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.