Evidence map›Paper›PMID 40706825›Full record

ArticleMitochondrion2025

PKM2 is a key regulator of cardiac lipid metabolism in mice.

Katie C Y Lee, Allison L Williams, Anastasia Fujimoto, Mariana Gerschenson, Connor Schuller, Noemi Polgar, Naghum Alfulaij, Briana K Shimada, Lucia A Seale, Ralph V Shohet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mitochondrion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katie C Y LeeDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Allison L WilliamsDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Anastasia FujimotoDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Mariana GerschensonDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Connor SchullerDepartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Noemi PolgarDepartment of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Naghum AlfulaijPacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Briana K ShimadaPacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Lucia A SealePacific Biosciences Research Center, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
Ralph V ShohetDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. Electronic address: shohet@hawaii.edu.

Funding

The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Kathryn Jaques Schunke · 2017 to 2026
$21.5M
Selenium Metabolism in the Heart: Impact of High Fructose and Low SeleniumP20GM139753 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Marla J Berry · 2022 to 2026
$13.3M
RESEARCH DESIGN, BIOSTATISTICS AND RESEARCH ETHICS COREG12MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 2012 to 2016
$13.0M
Pilot Project ProgramP30GM103341 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI SHOHET, RALPH V. · 2012 to 2016
$5.5M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
Selenium metabolism in cold-induced adaptive thermogenesisR01DK128390 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI SEALE, LUCIA ANDREIA · 2021 to 2025
$2.0M
Quantitative Mass Spectrometer for Targeted and Global Proteomics, MetabolomicsS10OD016387 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRAEBER, THOMAS G · 2013 to 2013
$593k
Live-Cell Imaging System with TIRF and PhotomanipulationS10OD028515 · OD · UNIVERSITY OF HAWAII AT MANOA · PI FARRAR, CHRISTINE · 2020 to 2020
$382k
NCI NIH HHS P30 CA071789NHLBI NIH HHS T32 HL115505NIDDK NIH HHS R01 DK128390NIGMS NIH HHS P20 GM113134NIGMS NIH HHS P20 GM139753NIGMS NIH HHS P30 GM103341NIH HHS S10 OD016387NIH HHS S10 OD028515NIMHD NIH HHS G12 MD007601NIMHD NIH HHS U54 MD007601
6 · The paper itself

Abstract

Deficiencies in lipid metabolism can have severe consequences for cardiac function. We previously showed that regulating glucose flux by pyruvate kinase 2 (PKM2) affects lipid synthesis and droplet abundance in cardiomyocytes. This study aims to examine how PKM2 regulates lipid metabolism in the heart. Indirect calorimetry suggested similar whole-body metabolism of PKM2 knockout (PKM2

Indexed as

Lipid MetabolismMyocardiumMyocytes, CardiacPyruvate KinaseAnimalsDiet, High-FatEnergy MetabolismFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPkm protein, mousePyruvate KinaseCardiomyocyteFatty acid oxidationMetabolism

Identifiers

PMID40706825
PMCPMC12393220

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.