Evidence map›Paper›PMID 40707142›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Advancing In Vivo Detection of T-Cell Function: Development and Preclinical Evaluation of

Mausam Kalita, Renesmee C Kuo, Samantha T Reyes, Deana Rae Crystal Colburg, Irene N Falk, David Anders, Ophir Vermesh, Samira Hayee, E Carmen Azevedo, Sydney C Nagy and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Engineering the next generation of cellular therapies for solid tumors: multi-specific armored CARs and TME reprogramming strategies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mausam KalitaMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Renesmee C KuoMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Samantha T ReyesMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Deana Rae Crystal ColburgDepartment of Pathology, Stanford University School of Medicine, Stanford, California.
Irene N FalkMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
David AndersMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Ophir VermeshMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Samira HayeeMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
E Carmen AzevedoMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Sydney C NagyMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Emily M DealMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Anthony An-Fa Dahm ChenMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California.
Christina S KongDepartment of Pathology, Stanford University School of Medicine, Stanford, California.
Federico SimonettaDivision of Hematology, Department of Oncology, Geneva University Hospitals, Geneva, Switzerland.
Anand GiddabasappaWorldwide Research, Development and Medicine, Pfizer Inc., New York, New York.
Edmund J KeliherWorldwide Research, Development and Medicine, Pfizer Inc., New York, New York.
Derek W BartlettWorldwide Research, Development and Medicine, Pfizer Inc., New York, New York.
Kevin P MarescaWorldwide Research, Development and Medicine, Pfizer Inc., New York, New York.
Michelle L JamesMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California; mljames@stanford.edu israt@stanford.edu.
Israt S AlamMolecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California; mljames@stanford.edu israt@stanford.edu.

Funding

Developing clinically relevant PET tracers to image T cell activation for improved cancer immunotherapy monitoringR01CA286998 · STANFORD UNIVERSITY · 2025 to 2025
$535k
NCI NIH HHS R01 CA286998
6 · The paper itself

Abstract

The variable response to cancer immunotherapies highlights a critical gap in our ability to predict and monitor treatment efficacy. To address this, there is an urgent clinical need for advanced molecular imaging technologies that can noninvasively and precisely assess whole-body immune responses. The OX40 receptor (CD134), a potent costimulatory molecule on T cells, serves as a highly specific marker of T-cell activation, an early and crucial event in immunotherapy efficacy. In this study, we report the development of a human OX40-specific radiotracer based on a clinically evaluated therapeutic-ivuxolimab-and assess its utility for PET imaging of activated T cells in vivo.

Indexed as

Positron-Emission TomographyRadioisotopesReceptors, OX40T-LymphocytesZirconiumAnimalsHEK293 CellsHumansMiceRadioactive TracersTissue DistributionRadioactive TracersRadioisotopesReceptors, OX40ZirconiumZirconium-89activated T cellsclinical translationhuman OX40 receptorimmunooncologyimmuno-PET

Identifiers

PMID40707142
PMCPMC12410289

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.