ArticleScientific reports2025
Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Previous research suggests a link between inflammatory proteins and rotator cuff tears, but the specific protein remains unclear. This two-sample Mendelian randomization (MR) study used genetic variants from a genome-wide association study (GWAS) of 14,824 primarily European participants. We analyzed 91 circulating inflammatory proteins using inverse variance weighting (IVW) and validated results with MR-Egger, the weighted median approach, and sensitivity tests. MR analysis identified three inflammatory proteins with significant associations in the IVW analysis: Interleukin-20 (IL-20) levels (OR = 1.225, 95% CI = 1.036 - 1.450, P = 0.044), Leukemia inhibitory factor levels (LIF) (OR = 1.380, 95% CI = 1.008 - 1.889, P = 0.044), and Signaling lymphocytic activation molecule (SLAM) (OR = 1.183, 95% CI = 1.059 - 1.321, P = 0.015). Elevated IL-20, LIF and SLAM increased the risk of rotator cuff tears. This MR study reveals a potential association between IL-20, LIF and SLAM and the risk of rotator cuff tears, providing insights into their pathogenesis and potential therapeutic targets.
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