Evidence map›Paper›PMID 40707649›Full record

ArticleAnnals of nuclear medicine2025

Distribution patterns of brown adipose tissue on FDG-PET/CT has age characteristics.

Yasuchiyo Toyama, Tomoya Kotani, Nagara Tamaki, Sachimi Yamada, Shimpei Akiyama, Yoshitomo Nakai, Taisei Kanayama, Chio Okuyama, Kei Yamada

Abstract read
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Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yasuchiyo ToyamaDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan. yasutiyo@koto.kpu-m.ac.jp.ORCID http://orcid.org/0009-0007-8457-2119
Tomoya KotaniDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
Nagara TamakiDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
Sachimi YamadaDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
Shimpei AkiyamaDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
Yoshitomo NakaiNational Center for Child Health and Development, Tokyo, Japan.
Taisei KanayamaDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
Chio OkuyamaClinical Research Center, Shiga General Hospital, Moriyama, Shiga, Japan.
Kei YamadaDepartment of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBrown adipose tissue (BAT) contributes to thermoregulation and energy expenditure. Although BAT is abundant in early childhood and declines with age, its distribution across age groups remains unclear. This study examined age-related BAT distribution using fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). MATERIALS AND

methodsA total of 8695 FDG-PET/CT scans performed for clinical purposes were retrospectively reviewed. FDG accumulation with a standardized uptake value (SUV) max > 1.5 in known BAT regions was considered positive. BAT distribution patterns were classified into T-type (positive accumulation in the supraclavicular or axillary region), I-type (positive accumulation in the cervical or paravertebral region without supraclavicular or axillary involvement), lipomatous hypertrophy of the interatrial septum (LHIS)-type (positive accumulation localized only to the LHIS), and others (cases not fitting any type).

resultsBAT accumulation was observed in 78 patients (0.9% prevalence): T-type (18), I-type (39), LHIS-type (18), and others (3). The mean ages for T-type, I-type, LHIS-type, and others were 29.8 ± 17.3, 73.6 ± 18.1, 72.9 ± 12.5, and 67.0 ± 11.5 years, respectively. Patients in the T-type group were significantly younger than those in the I-type- and LHIS-type groups (p < 0.01).

conclusionsThis study identified three BAT distribution types, with T-type occurring in mostly younger compared with the I-type and LHIS type. Recognizing these patterns may improve FDG-PET/CT diagnostic accuracy.

Indexed as

Adipose Tissue, BrownAgingFluorodeoxyglucose F18Positron Emission Tomography Computed TomographyAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansMaleMiddle AgedRetrospective StudiesYoung AdultFluorodeoxyglucose F18Age characteristicsBrown adipose tissueDistributionFDG-PET/CT

Identifiers

PMID40707649

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.