Evidence map›Paper›PMID 40707803›Full record

ReviewCurrent osteoporosis reports2025

Skeletal Health in Youth with Type 2 Diabetes.

Hanine AlArab, Anna Zenno, Melinda Pierce

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hanine AlArabDepartment of Pediatrics, University of Washington, 4800 Sand Point Way NE, M/S OC.7.820, PO Box 5371, Seattle, WA, 98145, USA. hanine.alarab@seattlechildrens.org.
Anna ZennoDepartment of Pediatrics, University of Washington, 4800 Sand Point Way NE, M/S OC.7.820, PO Box 5371, Seattle, WA, 98145, USA.
Melinda PierceDepartment of Pediatrics, University of Washington, 4800 Sand Point Way NE, M/S OC.7.820, PO Box 5371, Seattle, WA, 98145, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis paper will discuss the impact of type 2 diabetes (T2D) on skeletal health in youth. We will review the myriad physiology and pathophysiology of diabetic bone fragility with a focus on several new findings in the past five years. RECENT

findingsT2D is associated with increased fracture risk despite normal or high bone mineral density. Evidence suggests T2D may adversely affect bone density acquisition during peak bone mass development. The pathophysiology involves low bone turnover, reduced unmineralized bone matrix, and increased collagen glycation, contributing to compromised bone strength. Recent findings from mouse models, Mendelian randomization, and human studies highlight the interplay between metabolic imbalances, genetic influences, cellular dysfunction, and treatment strategies. Bone fragility is a frequently underdiagnosed complication in youth with T2D. Early intervention in youth is crucial to prevent the progression of metabolic and osteopathic disturbances associated with diabetes that can impact long-term skeletal health.

Indexed as

Bone DensityDiabetes Mellitus, Type 2Fractures, BoneAdolescentAnimalsBone RemodelingChildHumansBone fragilityBone mineral densityBone remodelingCytokinesObesityT2D

Identifiers

PMID40707803

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.