Evidence map›Paper›PMID 40707981›Full record

ArticleEuropean journal of medical research2025

uPAR and cFn as candidate protein biomarkers for identifying low response to rtPA in acute ischemic stroke.

Yilin Wang, Yuyou Huang, Fangfang Li, Ziping Han, Zhenhong Yang, Liyuan Zhong, Lingzhi Li, Haiping Zhao, Junfen Fan, Yangmin Zheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yilin Wang *Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Yuyou Huang *Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Fangfang LiInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Ziping HanInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Zhenhong YangInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Liyuan ZhongInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Lingzhi LiInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Haiping ZhaoInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Junfen FanInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Yangmin ZhengInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
Cesario BorlonganUniversity of South Florida, Tampa, FL, USA. cesvb@yahoo.com.
Yumin LuoInstitute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China. yumin111@ccmu.edu.cn.

Funding

Health Improvement and Research 2020-2-1032National Natural Science Foundation of China 82171301
6 · The paper itself

Abstract

backgroundRecombinant tissue plasminogen activator (rtPA) remains the main therapeutic for acute ischemic stroke (AIS). In clinical practice, the patients with AIS presenting low response to rtPA is commonly observed. Cognizant that the endothelial cell function is impaired in AIS, this study explored the endothelial cell-associated proteins as biomarkers that may identify low response to rtPA in AIS.

methodsSpearman's correlation test was performed to assess the relationship between urokinase-type plasminogen activator receptor (uPAR)/cellular fibronectin (cFn) and AIS outcomes. We defined "low response to rtPA" as the patients did not present a lower National Institute of Health Stroke Scale (NIHSS) than at admission and still suffered from poor outcome (modified Rankin Scale > 2) with rtPA use. Logistic regression analysis was used to assess the contribution of uPAR/cFn in identifying low response to rtPA in AIS. The relationship between uPAR/cFn and rtPA was further probed in Sprague-Dawley rats with experimental stroke induced by middle cerebral artery occlusion.

resultsBoth uPAR (P < 0.001) and cFn (P = 0.001) positively correlated with AIS favorable outcomes. uPAR (AUC = 68.2%, P = 0.007) and cFn (AUC = 71.3%, P = 0.002) can identify low response to rtPA. Additionally, uPAR (P = 0.015) and cFn (P = 0.004) were independent variables that predicted low response to rtPA. At 24 h and 72 h ischemic/reperfusion, rtPA tended to decrease cFn and uPAR plasma levels.

conclusionsOur study suggests that uPAR and cFn may serve as the candidate markers for identifying low response to rtPA in AIS. Patients with a low plasma level of cFn or uPAR may present low response to rtPA and still suffer from a poor outcome with rtPA.

Indexed as

Fibrinolytic AgentsFibronectinsIschemic StrokeReceptors, Urokinase Plasminogen ActivatorTissue Plasminogen ActivatorAgedAnimalsBiomarkersFemaleHumansMaleMiddle AgedRatsRats, Sprague-DawleyBiomarkersFibrinolytic AgentsFibronectinsPLAUR protein, humanReceptors, Urokinase Plasminogen ActivatorTissue Plasminogen ActivatorAcute ischemic strokeCFnOutcomeRtPAUPAR

Identifiers

PMID40707981
PMCPMC12288241

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.