Evidence map›Paper›PMID 40708198›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

Pharmacological Gq targeting prevents asthmatic airway remodeling.

Jennifer M Dietrich, Michaela Matthey, Annika Simon, Alexander Seidinger, Cynthia Koziol-White, Reynold A Panettieri, Bernd K Fleischmann, Daniela Wenzel

Abstract read
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In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer M DietrichInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Michaela MattheyInstitute of Physiology, Department of Systems Physiology, Medical Faculty, Ruhr University of Bochum, 44801 Bochum, Germany.
Annika SimonInstitute of Physiology, Department of Systems Physiology, Medical Faculty, Ruhr University of Bochum, 44801 Bochum, Germany.
Alexander SeidingerInstitute of Physiology, Department of Systems Physiology, Medical Faculty, Ruhr University of Bochum, 44801 Bochum, Germany.
Cynthia Koziol-WhiteRutgers Institute for Translational Medicine and Science, The State University of New Jersey, Rutgers, New Brunswick, NJ08901, USA.
Reynold A PanettieriRutgers Institute for Translational Medicine and Science, The State University of New Jersey, Rutgers, New Brunswick, NJ08901, USA.
Bernd K FleischmannInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Daniela WenzelInstitute of Physiology, Department of Systems Physiology, Medical Faculty, Ruhr University of Bochum, 44801 Bochum, Germany; Institute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, 53127 Bonn, Germany. Electronic address: daniela.wenzel@rub.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Airway remodeling is a critical hallmark of chronic asthma that is very difficult to treat. We have investigated this pathological process and found that local application of the pharmacological Gq inhibitor FR900359 (FR) attenuates the main features of airway remodeling, namely collagen deposition and goblet cell metaplasia in the chronic ovalbumin-induced asthma model in mice. We have explored the molecular mechanisms underlying the FR action and demonstrate that FR mitigates the growth of human lung fibroblasts in response to pathological stimuli in vitro. Likewise, FR inhibits mucus production and secretion in air-liquid interface cultures of human bronchial epithelial cells and in a human lung mucoepidermoid cell line. Notably, FR blocks mucus secretion in human lung slices from asthmatic patients. Thus, Gq proteins play a critical role in airway remodeling, hence pharmacological inhibition of Gq signaling represents a promising strategy for the treatment of chronic asthma.

Indexed as

Airway RemodelingAsthmaGTP-Binding Protein alpha Subunits, Gq-G11AnimalsCell LineDisease Models, AnimalFibroblastsGoblet CellsHumansLungMiceMucusOvalbuminSignal TransductionGTP-Binding Protein alpha Subunits, Gq-G11Ovalbuminairway remodelingasthmagoblet cell metaplasiaGq proteinsmucus production

Identifiers

PMID40708198
PMCPMC12848170

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.