Evidence map›Paper›PMID 40708564›Full record

ReviewLab on a chip2025

Present and future of smart functional materials as actuators in microfluidic devices.

Sepideh Izaddoust, Isabel Poves-Ruiz, Enrique Azuaje Hualde, Daniel Patko, Larisa Florea, Colm Delaney, Lourdes Basabe-Desmonts, Fernando Benito-Lopez

Abstract readReview
In one paragraph

Review in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sepideh IzaddoustMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Leioa, Spain. lourdes.basabe@ehu.eus.ORCID http://orcid.org/0000-0002-4227-1875
Isabel Poves-RuizMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Leioa, Spain. lourdes.basabe@ehu.eus.
Enrique Azuaje HualdeMicrofluidics Cluster UPV/EHU, BIOMICs microfluidics Group, Lascaray Research Centre, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. lourdes.basabe@ehu.eus.
Daniel PatkoMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Leioa, Spain. lourdes.basabe@ehu.eus.ORCID http://orcid.org/0000-0002-3553-2213
Larisa FloreaSchool of Chemistry & AMBER, The SFI Research Centre for Advanced Materials and BioEngineering Research, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-4704-2393
Colm DelaneySchool of Chemistry & AMBER, The SFI Research Centre for Advanced Materials and BioEngineering Research, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-4397-0133
Lourdes Basabe-DesmontsMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Leioa, Spain. lourdes.basabe@ehu.eus.
Fernando Benito-LopezMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, Leioa, Spain. lourdes.basabe@ehu.eus.ORCID http://orcid.org/0000-0003-0699-5507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of actuators in microfluidic systems is fundamental for accurate measurements and analyses, as they enable precise control over fluid flow by converting various forms of energy-including electrical, thermal, piezoelectric, and electromagnetic-into mechanical motion. The integration of actuators within microfluidic devices facilitates system miniaturization, allowing complex fluidic operations at the microscale. Actuators are essential components in micropumps, micromixers, microvalves, and other fluidic control elements, ensuring accurate handling of very small quantities of liquids. However, the selection of the material type for the actuator is highly dependent on the specific application, as well as on the material composition and structural configuration of the microfluidic device in which it will be integrated. Actuators can feature either moving or static components, and the use of hybrid materials allows for the development of innovative actuation mechanisms. Given the vast range of possible actuator-material combinations, selecting an appropriate actuation strategy is critical for optimal device performance. This review presents recent advancements in microfluidic actuation, with a particular emphasis on material innovations. It explores emerging actuator materials integrated within microfluidic channels, their fabrication and integration methods, activation mechanisms, and functional applications. Additionally, the review provides a comprehensive outlook on promising materials for future microfluidic actuator development.

Identifiers

PMID40708564
PMCPMC13007500

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.