Association of cardiorespiratory fitness with phenotypic age in younger population: a study based on the NHANES database.

Yi Shen, Wanying Shen, Yongyao Shen, Bo Chen, Cui Wu, Liying Jiang

Abstract read

In one paragraph

Article in Frontiers in sports and active living, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi Shen *Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China.

Wanying Shen *Department of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China.

Yongyao ShenDepartment of Epidemiology, College of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Bo ChenDepartment of Epidemiology, School of Public Health, Nantong University, Nantong, Jiangsu, China.

Cui WuDepartment of Non-Communicable Disease, Baoshan District Center for Disease Control and Prevention in Shanghai, Shanghai, China.

Liying JiangJiading Central Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Phenotypic age (PA), a novel signature of morbidity and mortality risk based on clinically collected parameters, is considered one of the most promising biomarkers for capturing aging. However, unequivocal evidence on the link between cardiorespiratory fitness (CRF), assessed by estimated maximal oxygen consumption (Vo Methods: Data from 3,069 participants in the National Health and Nutrition Examination Survey (NHANES) were included and further examined. CRF status was determined by Vo Results: In the multivariable logistical regression analysis, maintenance of CRF was significantly and inversely associated with PAA, demonstrating a decreased risk of 42% in the high CRF group [OR (95% CI): 0.58 (0.36, 0.96), Conclusions: Poor CRF may serve as a potential risk factor for accelerated biological aging (BA) in relatively young populations, and the existence of obesity could exacerbate the aging process. This represents a potential intervention target for promoting healthy aging across different age groups in the future.

Indexed as

cardiorespiratory fitnesshealthy agingNHANESobesityphenotypic age

Identifiers

PMID40708604

DOI10.3389/fspor.2025.1503135

PMCPMC12286991

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.