Evidence map›Paper›PMID 40708657›Full record

ArticleAdvances in pharmacological and pharmaceutical sciences2025

Safety, Tolerability, and Pharmacokinetics of NorUrsodeoxycholic Acid (Shilpa Medicare Limited, India) in Healthy Adults: Results From a Phase I Open-Label Dose-Escalation Study.

Veerendra Kumar Panuganti, Chandrasekhar Varma Alluri, Mamatha Reddy Dundigalla, Javeed Mohammad, Pavan Kumar Madala, Sanyasirao K S S V V

Abstract read
In one paragraph

Article in Advances in pharmacological and pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Veerendra Kumar PanugantiClinical Affairs, Shilpa Medicare Ltd, Hyderabad, Telangana, India.ORCID https://orcid.org/0009-0004-2623-5032
Chandrasekhar Varma AlluriMedical Affairs Department, Shilpa Medicare Ltd, Hyderabad, Telangana, India.ORCID https://orcid.org/0009-0009-5362-1007
Mamatha Reddy DundigallaMedical Affairs Department, Shilpa Medicare Ltd, Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0001-8930-7153
Javeed MohammadClinical Affairs, Shilpa Medicare Ltd, Hyderabad, Telangana, India.ORCID https://orcid.org/0009-0005-8983-2608
Pavan Kumar MadalaBioanalytical Laboratory, Shilpa Medicare Ltd, Hyderabad, Telangana, India.ORCID https://orcid.org/0009-0005-3297-3805
Sanyasirao K S S V VClinical Affairs, Shilpa Medicare Ltd, Hyderabad, Telangana, India.ORCID https://orcid.org/0009-0007-4125-1200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NorUrsodeoxycholic acid (norUDCA) is a side-chain-shortened derivative of ursodeoxycholic acid (UDCA) with specific pharmacological properties, including cholehepatic shunting, making it a promising candidate for a range of cholestatic and metabolic liver diseases. This phase I study evaluates the safety, tolerability, and pharmacokinetics of single ascending doses of norUDCA in healthy adults under fasting conditions. In this open-label, dose-escalation study, healthy adults (aged 18-45 years) were enrolled into 3 successive dose escalation cohorts, receiving norUDCA oral tablets of 500 mg (

Indexed as

24-norUrsodeoxycholic aciddose-limiting toxicityhealthy subjectsmaximum tolerated dosepharmacokineticphase I clinical trialssafety

Identifiers

PMID40708657
PMCPMC12289361

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.