Evidence map›Paper›PMID 40708689›Full record

ArticleFrontiers in neuroscience2025

Hemodynamic analysis of non-stenotic middle cerebral artery in patients with cerebral ischemia based on 4D flow MRI.

Yue Chen, Jiali Sun, Ying Sui, Ying Shi, Jianxiu Lian, Ping Yang, Shuai Lin, Min Lyu, Na Li, Tong Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue ChenDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jiali SunDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ying SuiDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ying ShiDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jianxiu LianDepartment of Advisory Clinical Scientist C&TS North, Philips Healthcare, Beijing, China.
Ping YangDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Shuai LinDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Min LyuDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Na LiDepartment of Medical imaging, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Tong ZhangDepartment of Medical imaging, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Wei WangDepartment of MRI Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Changes in cerebral hemodynamics in symptomatic states among patients with cerebral ischemia remain unclear. This study endeavors to investigate the characteristics of hemodynamics distribution within the non-stenotic middle cerebral artery (MCA) in patients with anterior circulation cerebral ischemia. Materials and methods: All subjects were prospectively recruited in this study. According to the clinical features of cerebral ischemia symptoms, they were divided into ischemia group and healthy group. MCA was further divided into proximal, curved, and distal segments based on the vascular morphology. Hemodynamic parameters, including flow, peak flow velocity, wall shear stress (WSS), pressure and energy loss (EL) were measured for each segment of the MCA in both groups using 4D flow MRI. The hemodynamic parameters of the proximal, curved, and distal MCA segments were compared within the group, and the influence of MCA morphology on hemodynamics was analyzed. Additionally, the hemodynamic parameters of the proximal, curved, and distal MCA segments were compared between the healthy and the ischemic groups to analyze the hemodynamic changes in the MCA among patients with cerebral ischemia. Results: A total of 50 MCAs were included in healthy group and 30 MCAs in ischemia group. There were no statistically significant differences in gender, age, heart rate, presence of hypertension and Body mass index (BMI) between the two groups. Results showed that the proximal segment had the highest blood volume (all Conclusion: The distribution of hemodynamics in MCA is similar between anterior circulation cerebral ischemia patients and healthy group. In the ischemic group, the peak blood flow velocity, circumferential WSS, and EL of MCA were lower compared to the healthy group. The reduced flow velocity and the decrease of circumferential WSS in the curved section may be contributing factors to cerebrovascular events.

Indexed as

4D flow MRIcerebral ischemiahemodynamicsmiddle cerebral arterypeak velocityWSS = wall shear stress

Identifiers

PMID40708689
PMCPMC12287126

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.