ReviewFrontiers in pharmacology2025
Beyond the heart: a review exploring non-cardiovascular effects of vasoactive agents.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Efficacy of milrinone combined with norepinephrine in improving hemodynamics and protecting liver/kidney function in patients with septic shock.Pakistan journal of medical sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasoactive agents, traditionally recognized for their roles in cardiovascular regulation, have garnered increasing attention for their non-cardiovascular effects across various physiological systems. This review explores the multifaceted roles of vasoactive agents such as catecholamines, vasopressin, and angiotensin II beyond their cardiovascular implications. We examine the mechanisms of action, focusing on receptor interactions and the implications for various physiological systems. Key areas of impact include the central nervous system, where vasoactive agents influence mood, cognition, and neurological function, alongside potential neurotoxicity. Additionally, we discuss gastrointestinal effects, including motility and secretion, as well as renal implications related to blood flow and acute kidney injury risk. The endocrine effects are also addressed, particularly regarding insulin and glucagon secretion. Furthermore, we analyze hematological effects on coagulation and endothelial function, emphasizing the risk factors for thromboembolic events. The clinical implications of this review underscore the importance of monitoring non-cardiovascular effects in patient management and developing strategies to mitigate associated risks. Future research should focus on unraveling the detailed mechanisms of vasoactive agent-receptor interactions and their resulting organ responses, to minimize complications arising from clinical use.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.