Evidence map›Paper›PMID 40709250›Full record

ArticleResearch square2025

Multi-omic insights from a multi-ancestry genome-wide meta-analysis of ankylosing spondylitis reveal novel pathways of disease susceptibility.

Matthew Brown, Zhixiu Li, Xin Wu, Nicholas Harvey, Jose Garrido-Mesa, Xiaobing Wang, Zhihao Xu, Geng Wang, Helena Marzo-Ortega, Dennis McGonagle and 27 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Matthew BrownKing's College London.ORCID 0000-0003-0538-8211
Zhixiu LiSchool of Public Health and Emergency Management, Southern University of Science and Technology.
Xin WuDepartment of Rhuematology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, China.
Nicholas HarveyDepartment of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London.
Jose Garrido-MesaUnidad investigación clínica de cáncer de pulmón, H12O-CNIO, Instituto de Investigación Hospital 12 de Octubre/Centro Nacional de Investigaciones Oncológica.
Xiaobing WangDepartment of Rheumatology and Immunology, National key laboratory for Immunity and Inflammation, Shanghai Changzheng Hospital, Naval Medical University.
Zhihao XuSchool of Public Health and Emergency Management, Southern University of Science and Technology.
Geng WangThe University of Queensland.ORCID 0000-0003-2478-2919
Helena Marzo-OrtegaLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds.ORCID 0000-0002-9683-3407
Dennis McGonagleLeeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, University of Leeds.
Ann MorganLeeds University.ORCID 0000-0003-1109-624X
Nurullah AkkocDokuz Eylül University.ORCID 0000-0002-3718-171X
Gokce Kenar ArtinSchool of Medicine, Division of Rheumatology, Dokuz Eylül University.
Gary MacfarlaneSchool of Medicine and Dentistry, University of Aberdeen.
Gareth JonesUniversity of Aberdeen.
Linda BradburyQueensland University of Technology.
Paul LeoQUT.
Kate ZimmermanSchool of Biomedical Sciences, Queensland University of Technology.
Emma DuncanUniversity of Queensland.
Julia BrownCollege of Medicine and Dentistry, James Cook University.
Tony MerrimanUniversity of Alabama at Birmingham.ORCID 0000-0003-0844-8726
Simon StebbingsDepartment of Medicine, Dunedin School of Medicine, University of Otago.
Mahdi MahmoudiResearch Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences and Rheumatology Research Center, Tehran University of Medical Sciences.
Ahmadreza JamshidiResearch Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences and Rheumatology Research Center, Tehran University of Medical Sciences.
Elham FarhadiResearch Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences and Rheumatology Research Center, Tehran University of Medical Sciences.
Nigil HaroonDivision of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Schroeder Arthritis Institute.
Robert InmanDivision of Rheumatology, Department of Medicine, University Health Network, University of Toronto, Schroeder Arthritis Institute.
Maxime BrebanUMR1173, Université Paris Saclay, Université de Versailles St Quentin en Yvelines, Inserm, Infection et Inflammation.ORCID 0000-0002-6932-9395
Gensler LianneUniversity of California, San Francisco.
Michael WardNational Institutes of Health.
B WordsworthBotnar Research Centre.
Michael WeismanStanford University.
David EvansUniversity of Queensland.ORCID 0000-0003-0663-4621
Tony KennaQueensland University of Technology.
Tae-Hwan KimHanyang University Hospital for Rheumatic Diseases.ORCID 0000-0002-3542-2276
John ReveilleMemorial Hermann Texas Medical Centre.
Huji XuDepartment of Rheumatology and Immunology, National Key Laboratory for Immunity and Inflammation, Shanghai Changzheng Hospital, Naval Medical University.

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI WANG, CHRISTINA C. · 1985 to 2011
$74.2M
FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITISR01AR046208 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI REVEILLE, JOHN DUFFIN · 1999 to 2003
$4.2M
NCRR NIH HHS M01 RR000425NIAMS NIH HHS R01 AR046208Wellcome Trust
6 · The paper itself

Abstract

We report the largest genome-wide association study meta-analysis in ankylosing spondylitis (AS) to date (25,645 cases, 71,224 controls), identifying 27 novel loci and 86 independent genetic associations. Variations in

Identifiers

PMID40709250
PMCPMC12288525

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.