Evidence map›Paper›PMID 40709279›Full record

ArticleResearch square2025

Elevated apolipoprotein C3 heightens atherosclerosis risk by mediating arterial accumulation of free cholesterol and local inflammation in diabetes.

Jenny E Kanter, Cheng-Chieh Hsu, Farah Kramer, Baohai Shao, Tomas Vaisar, Laura J den Hartigh, Abigail Reed, Jason Luo, Alan Tran, Jingjing Tang and 13 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jenny E KanterDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Cheng-Chieh HsuDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.ORCID 0000-0002-3423-7159
Farah KramerDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Baohai ShaoDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Tomas VaisarDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Laura J den HartighDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Abigail ReedDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Jason LuoDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Alan TranDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Jingjing TangDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Henry MangalapalliDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Jocelyn CervantesDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Masami Shimizu-AlbergineDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.
Peter D ReavenPhoenix VA Health Care System, Phoenix, AZ 85012.
Juraj KoskaPhoenix VA Health Care System, Phoenix, AZ 85012.
Majken K JensenDepartment of Public Health, University of Copenhagen, 1353 Copenhagen, Denmark.
Brandon S J DaviesDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0002-7168-8522
Edward A FisherDiabetes, and Metabolism, and Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0001-9802-143X
Nicholas O DavidsonDepartment of Medicine, Division of Gastroenterology, Washington University School of Medicine, Saint Louis, MO 63110.
Nathan O StitzielCardiovascular Division, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-4963-8211
Adam E MullickIonis Pharmaceuticals, Inc., Carlsbad, CA 92010, USA.
Ira J GoldbergHolman Division of Endocrinology, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016.ORCID https://orcid.org/0000-0002-8701-2201
Karin E BornfeldtDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98109.ORCID 0000-0001-9208-6523

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Triglycerides, Diabetes and Cardiovascular DiseaseP01HL151328 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 2020 to 2026
$19.6M
Identifying new strategies for prevention of cardiovascular complications of diabetesR35HL150754 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E · 2020 to 2025
$6.2M
Lipid-associated macrophages in diabetic kidney diseaseR01DK121756 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jenny E. Kanter · 2020 to 2026
$2.7M
Distinct functions of adipocyte-derived FGF21 in obesityR01DK135756 · NIDDK · UNIVERSITY OF WASHINGTON · PI Laura J. den Hartigh · 2024 to 2026
$1.5M
NHLBI NIH HHS P01 HL151328NHLBI NIH HHS R35 HL150754NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK121756NIDDK NIH HHS R01 DK135756
6 · The paper itself

Abstract

Cardiovascular outcome trials are being considered for therapeutics that silence apolipoprotein C3 (APOC3) or angiopoietin-like 3 (ANGPTL3) because of their abilities to lower triglyceride-rich lipoproteins (TRLs) and their remnants in individuals with increased cardiovascular disease (CVD) risk

Identifiers

PMID40709279
PMCPMC12288534

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.