ArticleDermatology reports2026
Rate of growth of Merkel cell carcinoma: a unique photographic evidence.
Article in Dermatology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immune checkpoint inhibitor therapy for treatment of periocular Merkel cell carcinoma: A systematic review of clinical outcomes and safety.Indian journal of ophthalmology · 2026Pooled it
- Optimizing surgical margins in the treatment of eyelid Merkel cell carcinoma: a tertiary center experience and literature review.Frontiers in ophthalmology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin tumor, mainly linked to Merkel cell polyomavirus (MCPyV) and less often to ultraviolet exposure. Additional risk factors include advanced age and immunosuppression. Although MCC is known to grow rapidly, its exact growth rate has not yet been described. We report a case of a 73-year-old man who developed de novo MCC on the lower eyelid while undergoing immunotherapy with nivolumab. Clinical photographs document the absence of disease in March 2024 and the appearance of a 7 mm papule in October 2024. Histology confirmed the diagnosis. This case represents rare visual evidence of MCC's rapid progression, suggesting an estimated growth rate of approximately 1 mm/month. A controversial aspect is that MCC developed despite ongoing treatment with a programmed death (PD)-1 checkpoint inhibitor, currently recommended for this cancer. Although anecdotal, this case highlights MCC's progression and the need for further research and new therapies.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.