Evidence map›Paper›PMID 40709942›Full record

ArticleJournal of virology2025

Inhibition of interferon signaling improves rabbit calicivirus replication in biliary organoid cultures.

Elena Smertina, Megan Pavy, Nias Y G Peng, Omid Fahri, Maria Jenckel, Tanja Strive, Michael Frese, Ina L Smith

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena Smertina *Commonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.ORCID 0000-0003-2207-6375
Megan Pavy *Commonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.
Nias Y G Peng *Commonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.
Omid FahriCommonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.
Maria JenckelCommonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.
Tanja StriveCommonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.
Michael FreseCommonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.ORCID 0000-0002-1059-2375
Ina L SmithCommonwealth Scientific and Industrial Research Organisation, Health and Biosecurity, Black Mountain, Canberra, Australian Capital Territory, Australia.ORCID 0000-0001-5807-3737

Funding

Meat and Livestock Australia P.PSH.1059
6 · The paper itself

Abstract

The IMPORTANCE: In this work, we describe the use of an interferon inhibitor to enhance the permissiveness of our recently developed rabbit liver-derived organoid cell culture system for rabbit hemorrhagic disease viruses. The data show that interferon inhibitors offer a simple and cost-effective approach to increase the replication of difficult-to-grow viruses in culture systems that are not interferon-deficient.

Indexed as

Hemorrhagic Disease Virus, RabbitInterferonsOrganoidsSignal TransductionVirus ReplicationAnimalsCaliciviridae InfectionsLiverNitrilesPyrazolesPyrimidinesRabbitsInterferonsNitrilesPyrazolesPyrimidinesruxolitinibliver organoidsrabbitRHDVRHDV2Ruxolitinib

Identifiers

PMID40709942
PMCPMC12363232

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.