Evidence map›Paper›PMID 40710203›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

The Effect of Prophylactic Hepatoprotective Therapy on Drug-Induced Liver Injury in Patients Undergoing Chemotherapy for Cervical Cancer: A Retrospective Analysis Based on Propensity Score Matching.

Zhe Liu, Dongliang Yuan, Jun Chang, Lei Shi, Jingmeng Li, Mei Zhao, Qi Yang

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhe LiuDepartment of Pharmacy, Xi'an Daxing Hospital, Yan'an University, Xi'an 710082, China.ORCID 0009-0004-1766-2032
Dongliang YuanDepartment of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
Jun ChangDepartment of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
Lei ShiDepartment of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
Jingmeng LiDepartment of Pharmacy, Xi'an Daxing Hospital, Yan'an University, Xi'an 710082, China.
Mei ZhaoDepartment of Pharmacy, Xi'an Daxing Hospital, Yan'an University, Xi'an 710082, China.
Qi YangDepartment of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This retrospective study aimed to assess the effectiveness of prophylactic hepatoprotective therapy in decreasing the incidence of drug-induced liver injury (DILI) among patients with cervical cancer undergoing chemotherapy. The analysis was performed on patients with cervical cancer who received chemotherapy at a tertiary hospital between September 2019 and August 2020. Propensity score matching (PSM) was utilized to equilibrate baseline characteristics between the treatment group, which received prophylactic hepatoprotective drugs, and the control group, which did not receive prophylaxis. The incidence and severity of liver injury were evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Out of the 609 patients initially screened, 299 were included following PSM, with 105 in the treatment group and 194 in the control group. There were no significant differences in the incidence of liver injury (21.90% vs. 18.04%,

Indexed as

Antineoplastic AgentsChemical and Drug Induced Liver InjuryProtective AgentsUterine Cervical NeoplasmsAdultAgedFemaleHumansMiddle AgedPropensity ScoreRetrospective StudiesAntineoplastic AgentsProtective Agentscervical cancerchemotherapydrug-induced liver injuryhepatoprotective drugspropensity score matching

Identifiers

PMID40710203
PMCPMC12293727

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.