Evidence map›Paper›PMID 40710331›Full record

ArticleCells2025

Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits

Neeraja Purandare, Vignesh Pasupathi, Yue Xi, Vikram Rajan, Caleb Vegh, Steven Firestine, Tamas Kozicz, Andrew M Fribley, Lawrence I Grossman, Siddhesh Aras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Neeraja PurandareCenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Vignesh PasupathiCenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-3477-4659
Yue XiDepartment of Pediatrics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Vikram RajanCenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Caleb VeghCenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0009-0009-8472-7672
Steven FirestineDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Tamas KoziczDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Andrew M FribleyDepartment of Pediatrics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-2046-1600
Lawrence I GrossmanCenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-1059-9358
Siddhesh ArasCenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USA.

Funding

US Army Medical Research Command award W81XWH2110402
6 · The paper itself

Abstract

The mitochondrial regulator MNRR1 is reduced in several pathologies, including the mitochondrial heteroplasmic disease MELAS, and genetic restoration of its level normalizes the pathological phenotype. Here, we investigate the upstream mechanism that reduces MNRR1 levels. We have identified the hypoxic regulator HIF2α to bind the MNRR1 promoter and inhibit transcription by competing with RBPJκ. In MELAS cells, there is a pseudohypoxic state that transcriptionally induces

Indexed as

Basic Helix-Loop-Helix ProteinsMELAS SyndromeMitochondrial ProteinsTranscription, GeneticEndothelial PAS Domain-Containing Protein 1FibroblastsHumansMitochondriaProtein StabilityBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Mitochondrial Proteinsdrug repurposingheteroplasmyhypoxia

Identifiers

PMID40710331
PMCPMC12293968

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.