Evidence mapPaperPMID 40710368Full record

ArticleCells2025

Integrative Multi-Omics Profiling of Rhabdomyosarcoma Subtypes Reveals Distinct Molecular Pathways and Biomarker Signatures.

Aya Osama, Ahmed Karam, Abdelrahman Atef, Menna Arafat, Rahma W Afifi, Maha Mokhtar, Taghreed Khaled Abdelmoneim, Asmaa Ramzy, Enas El Nadi, Asmaa Salama and 2 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aya OsamaProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.
Ahmed KaramProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.
Abdelrahman AtefProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.ORCID 0009-0005-4485-6315
Menna ArafatFaculty of Medicine, Mansoura University, Mansoura 35516, Egypt.ORCID 0009-0000-0001-9666
Rahma W AfifiProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.ORCID 0009-0000-3646-6425
Maha MokhtarProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.
Taghreed Khaled AbdelmoneimProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.ORCID 0000-0001-9171-863X
Asmaa RamzyProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.
Enas El NadiRadio Diagnosis Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.
Asmaa SalamaPathology Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.
Emad ElzayatBiotechnology Department, Faculty of Science, Cairo University, Cairo 11562, Egypt.ORCID 0000-0002-9834-1289
Sameh MagdeldinProteomics and Metabolomics Unit, Basic Research Department, Children's Cancer Hospital (CCHE-57357), Cairo 57357, Egypt.ORCID 0000-0002-7507-9935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, comprises embryonal (ERMS) and alveolar (ARMS) subtypes with distinct histopathological features, clinical outcomes, and therapeutic responses. To better characterize their molecular distinctions, we performed untargeted plasma proteomics and metabolomics profiling in children with ERMS (

Indexed as

Biomarkers, TumorMetabolomicsProteomicsRhabdomyosarcomaChildChild, PreschoolFemaleGene Expression Regulation, NeoplasticHumansInfantMaleMultiomicsSignal TransductionBiomarkers, Tumoralveolar RMS (ARMS)embryonal RMS (ERMS)metabolomicsmulti-omics integrationproteomicsrhabdomyosarcoma

Identifiers

PMID40710368
PMCPMC12293488

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.