Evidence map›Paper›PMID 40710498›Full record

ArticleMarine drugs2025

The Invertebrate-Derived Antimicrobial Peptide Cm-p5 Induces Cell Death and ROS Production in Melanoma Cells.

Ernesto M Martell-Huguet, Daniel Alpízar-Pedraza, Armando Rodriguez, Marc Zumwinkel, Mark Grieshober, Fidel Morales-Vicente, Ann-Kathrin Kissmann, Markus Krämer, Steffen Stenger, Octavio L Franco and 3 more

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Computer-Aided Design ofACS medicinal chemistry letters · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ernesto M Martell-HuguetCenter for Protein Studies, Faculty of Biology, University of Havana, 25 and I, La Habana 10400, Cuba.ORCID 0000-0001-6494-800X
Daniel Alpízar-PedrazaCenter for Pharmaceutical Research and Development, 26th Avenue, No 1605, Nuevo Vedado, La Habana 10400, Cuba.ORCID 0000-0002-0281-680X
Armando RodriguezCore Facility for Functional Peptidomics, Ulm Peptide Pharmaceuticals (U-PEP), Faculty of Medicine, Ulm University, 89081 Ulm, Germany.ORCID 0000-0001-5921-3770
Marc ZumwinkelInstitute of Medical Microbiology and Hygiene, University Clinic of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Mark GrieshoberInstitute of Medical Microbiology and Hygiene, University Clinic of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Fidel Morales-VicenteSynthetic Peptides Group, Center for Genetic Engineering and Biotechnology, La Habana 10600, Cuba.ORCID 0000-0003-2037-239X
Ann-Kathrin KissmannInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0000-0002-7164-0166
Markus KrämerInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0009-0009-6298-3296
Steffen StengerInstitute of Medical Microbiology and Hygiene, University Clinic of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Octavio L FrancoCenter for Biochemical and Proteomics Analyses, Catholic University of Brasilia, Brasilia 71966-700, Brazil.ORCID 0000-0001-9546-0525
Ludger StändkerCore Facility for Functional Peptidomics, Ulm Peptide Pharmaceuticals (U-PEP), Faculty of Medicine, Ulm University, 89081 Ulm, Germany.ORCID 0000-0002-8436-4260
Anselmo J Otero-GonzalezCenter for Protein Studies, Faculty of Biology, University of Havana, 25 and I, La Habana 10400, Cuba.ORCID 0000-0002-1719-0117
Frank RosenauInstitute of Pharmaceutical Biotechnology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.ORCID 0000-0002-9297-6419

Funding

Deutsche Forschungsgemeinschaft 316249678Deutsche Forschungsgemeinschaft 465229237Federal Ministry of Education and Research DLR CUB 17WTZ-014/01DN18009German Academic Exchange Service 57592717-Glacier
6 · The paper itself

Abstract

Nowadays, healthcare systems face two global challenges: the rise of multidrug-resistant pathogens and the growing incidence of cancer. Due to their broad spectrum of activities, antimicrobial peptides emerged as potential alternatives against both threats. Our group previously described the antifungal activity of the α-helical peptide Cm-p5, a derivative of the natural peptide Cm-p1, isolated from the coastal mollusk

Indexed as

Antimicrobial PeptidesAntineoplastic AgentsMelanomaReactive Oxygen SpeciesAnimalsCell DeathCell Line, TumorCell MembraneCell ProliferationHumansMolecular Dynamics SimulationAntimicrobial PeptidesAntineoplastic AgentsReactive Oxygen Speciesanti-cancer peptidecell deathCm-p5membrane disruptionROS

Identifiers

PMID40710498
PMCPMC12299483

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.