Evidence map›Paper›PMID 40711044›Full record

ArticleToxics2025

Immunotoxicity Studies on the Insecticide 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (MPEP) in Hsd:Harlan Sprague Dawley SD

Victor J Johnson, Stefanie C M Burleson, Michael I Luster, Gary R Burleson, Barry McIntyre, Veronica G Robinson, Reshan A Fernando, James Blake, Donna Browning, Stephen Cooper and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Victor J JohnsonBurleson Research Technologies, Inc., Morrisville, NC 27560, USA.ORCID 0000-0002-3471-6483
Stefanie C M BurlesonBurleson Research Technologies, Inc., Morrisville, NC 27560, USA.
Michael I LusterBurleson Research Technologies, Inc., Morrisville, NC 27560, USA.
Gary R BurlesonBurleson Research Technologies, Inc., Morrisville, NC 27560, USA.
Barry McIntyreDivision of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27560, USA.
Veronica G RobinsonDivision of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27560, USA.
Reshan A FernandoRTI International, Research Triangle Park, NC 27713, USA.
James BlakeRTI International, Research Triangle Park, NC 27713, USA.
Donna BrowningRTI International, Research Triangle Park, NC 27713, USA.
Stephen CooperRTI International, Research Triangle Park, NC 27713, USA.
Shawn HarrisDLH, LLC, Bethesda, MD 20817, USA.
Dori R GermolecDivision of Translational Toxicology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27560, USA.

Funding

NIEHS NIH HHS ES103374-01NIEHS NIH HHS GS-00F-173CA/75N96022F00055NIEHS NIH HHS HHSN273201400017CNIEHS NIH HHS HHSN273201400022C
6 · The paper itself

Abstract

The broad-spectrum insect growth regulator (IGR) and insecticide 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (MPEP; also known as pyriproxyfen) is increasingly being used to address public health programs for vector control, initiated by the spread of Zika virus in 2015-2016. While considered relatively safe for humans under normal conditions, limited toxicology data are available. Current studies were undertaken to address the data gap regarding potential immunotoxicity of MPEP, with particular emphasis on host resistance to viral infection. Hsd:Harlan Sprague Dawley SD

Indexed as

2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridineimmunosuppressionimmunotoxicologyinsecticide toxicityMPEPpyridinepyriproxyfen

Identifiers

PMID40711044
PMCPMC12300427

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.